Volume 16, Issue 62 (7-2007)                   jour guilan uni med sci 2007, 16(62): 95-105 | Back to browse issues page

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Asgharnia M, Mehrafza M. Survey the Effect of Piroxicam Treatment on Pregnancy Rate in Intracytoplasmic Sperm Injection (ICSI) before Embryo Transfer. jour guilan uni med sci. 2007; 16 (62) :95-105
URL: http://journal.gums.ac.ir/article-1-386-en.html
Abstract:   (9809 Views)
Abstract Introduction: In the past 20 years, numerous studies have been done to improve the implantation process in ICSI. Several factors like: embryo quality, endometrial reception and etc. Can influence on uterine implantation. Uterine contraction at the time of embryo transfer alters pregnancy rates (PRs) after IVF. The first and the most important factors consist of avoiding the initiation of uterine contractility. Objective: Survey the effect of Piroxicam treatment on the pregnancy rate in ICSI. Materials and Methods: This was a clinical trial and double blind randomized study. 500 consecutive cycles of ICSI-ET including infertile couples were divided randomly into treatment and control groups. After blood studies (hormonal tests, …), Sonography, Hystrosalpingography and etc, the women with uterine problems like Myoma, Asherman's Syndrome and… were excluded. Then all of the couples with male factor, tubal factor, ovulatory factor and unexplained factors were included in this study. Control ovarian hyperstimulation(COH) was performed with long protocol. The case group (250 cycles) received an oral dose of 10 mg of Piroxicam, and the control group (250 cycles) received a placebo, 1-2 hours before fresh ET. An informed consent form was obtained for each patient's treatment. The main outcome was pregnancy rate (PR). Results: Data showed that the mean of age females' age and duration of infertility didn't have statistically significant between two groups. There was not statistically significant between the mean of Estradiol in 3rd day of period and mean of Estradiol in the day of HCG injection, mean of FSH, mean of LH, mean of follicle and mean of endometrial thickness in two groups (P>0.05). Also between the mean number of Oocyte retrieval (metaphase II), 2PN, embryo cleaved, embryo transferred and pregnancy rate in two Groups (P>0.05). Conclusion: Piroxicam treatments don't effect on PR in ICSI and it's appears that it isn't effective in the priming of uterus before ET.
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Type of Study: Research | Subject: Special
Received: 2013/12/30 | Accepted: 2013/12/30 | Published: 2013/12/30

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