Volume 15, Issue 57 (4-2006)                   jour guilan uni med sci 2006, 15(57): 59-64 | Back to browse issues page

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Imantalab V, Haghighi M. Effect of Hemodynamic Propofol and Thiopemtal Sodium and During Electeroconvulsive Therapy. jour guilan uni med sci. 2006; 15 (57) :59-64
URL: http://journal.gums.ac.ir/article-1-482-en.html
Abstract:   (6191 Views)
Abstract Introduction: For safe conduct of electro convulsive therapy (ECT) and decreasing the tissue physiological complication general anesthesia is recommended to patients. Objective: In this study we compared thiopental sodium and propofol as induction agent for ECT. Materials and Methods: Twenty-five patients each undergoing at least 2 sessions of ECT at the psychiatry department were included in the study. Each patient either received thiopental sodium or propofol for induction in a randomized manner. They are in ASA class I, II and don’t have any contraindication for ECT. Patients with cardio- vascular problem and stroke were excluded from study. Patients were anesthetized in a randomized manner wit h 2.5mg/kg thiopental and 1mg/kg propofol in separate session. Muscle relaxant drug dose was the same for all patients. Amount of energy shock administration can lead to effective tonic-clonic seizure in-patient. Mean arterial pressure and heart rate in 1,5 and 10 minute after ECT were evaluated. Meanwhile duration of seizure and verbal eye opening, discharge from recovery room and breathing rhythm in two groups were also evaluated. Results: The mean arterial pressure in proopfol group in 1,5 and 10 minute after ECT was respectively: (88.26±13.03) mm Hg, (92.50±10.01) mm Hg, (87.56± 10.24) mm Hg. And in thiopental group in 1,5 and 10 minutes after ECT was respectively: (84.97±10.28) mm Hg, (104.13±7.85) mm Hg, (96.73±9.08) mm Hg, that was statistically significant (P< 0.00). In the assessment of mean heart rate in 1,5 and 10 minute after ECT in thiopental group was respectively:(82.2±9.07)min, (110.04±7.08) min, (101.65±10.08) min. And in propofol group was respectively: (85.77±12.04) min, (98.75±11.02) min, (81.46±12.01)min which was statistically significant (P<0.05). Duration of seizure in thiopental and propofol group was respectively: (31.08±4.13)min, (25.76±3.38) min. Time to verbal eye opening in thiopental and propofol group was respectively(5.04±1.36) min, (3.28±0.89)min. Discharging from recovery in thiopental and propofol group was respectively: (13.68±1.72) min, (10.28±1.05) min. Breathing rhythm time in thiopental and propofol group was respectively: (5.02±0.3)min (4.74±0.3)min which was statistically significant (P< 0.001). Conclusion: Propofol offered a superior-hemodynamic stability during the procedure and a quick recovery from sleep. Propofol was found to be a better induction agent for ECT as compared to thiopental sodium.
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Type of Study: Research | Subject: Special
Received: 2014/01/18 | Accepted: 2014/01/18 | Published: 2014/01/18

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