Volume 23, Issue 89 (4-2014)                   jour guilan uni med sci 2014, 23(89): 8-14 | Back to browse issues page

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Rostampour M, Aghaei I, Soltani B, Khakpour B. Effect of Matricaria chamomilla Hydro-alcoholic Extract on PTZ-induced Seizure in Male Mice. jour guilan uni med sci. 2014; 23 (89) :8-14
URL: http://journal.gums.ac.ir/article-1-563-en.html
Guilan University of Medical Sciences
Abstract:   (6194 Views)
Abstract Introduction: Regarding to chronic nature of epilepsy, side effects and resistance to chemical drugs, herbal medicine have received remarkable interest. Matricaria chamomilla is a medicinal plant that has been used as tranquilizer and anticonvulsant in traditional medicine. Objective: To determine the anticonvulsant effects of hydro-alcoholic extract of Matricaria chamomilla on PTZ-induced seizure in male rats. Materials and Methods: This experimental study was carried out on 48 NMRI albino male rats weighing 20-25g. They were divided randomly into six groups. All groups were injected intraperitoneally. The negative and positive control groups received saline (10 ml/1000g) and Phenobarbital (40 mg/kg), respectively. The four test groups received 500, 600, 800 and 1000 mg/kg of extract. In order to provoke convulsion, pentylenetetrazol (PTZ) was injected (80 mg/kg) to all groups after 45 minutes and initiation time of tonic-clonic seizures and mortality within 24 h were measured. Results: The results indicated that positive control group animals, which received Phenobarbital, were with no seizure and death. Different doses of extract delayed the initiation time of tonic-clonic seizures, in comparison with control group (saline). The delay was significant at 600 mg/kg (P< 0.05) and 800 and 1000 mg/kg (P< 0.001). Also, the extract decreased the 24 h death. This was significant at 800 and 1000 mg/kg (P<0. 01) and 600 mg/kg (P< 0.05). Conclusion: The present study showed that hydro-alcoholic extract of Matricaria chamomilla has inhibitive effect on PTZ-induced seizure in male rats. Conflict of interest: non declared
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Type of Study: Research | Subject: Special
Received: 2014/03/9 | Accepted: 2014/03/9 | Published: 2014/03/9

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