Volume 22, Issue 85 (4-2013)                   jour guilan uni med sci 2013, 22(85): 88-95 | Back to browse issues page

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Roghani M, Omid Malayeri S, Malayeri S. Effect of Tribulus Terrestris Oral Feeding on Learning and Memory in Streptozotocin-diabetic Rats: Investigating the Role of lipid Peroxidation. jour guilan uni med sci. 2013; 22 (85) :88-95
URL: http://journal.gums.ac.ir/article-1-86-en.html
Shahed University
Abstract:   (6268 Views)
Introduction: Diabetes in long term is associated with learning and memory deficits. Given the Anti-diabetic and antioxidant activities of Tribulus terrestris (TT). Objective: to evaluate the effect of oral administration of Tribulus terrestris on learning and memory in diabetic rats. Materials and Methods: Thirty two Wistar rats were divided into control, TT-treated control, diabetic, and TT-treated diabetic groups. To evaluate their learning and memory, initial (IL) and step-through latencies (STL) were determined at the end of study using passive avoidance test and alternation behavior percentage was obtained using Y maze. Level of malondialdehyde in hippocampal homogenate was also measured at the end of the study. Results: STL significantly decreased in diabetic group (p<0.01) and TT-treated diabetic group showed a significantly higher STL (p<0.01), compared to the diabetic counterparts. Alternation percentage was significantly lower in the diabetic group relative to the controls (p<0.01) and treated diabetic group did show a significant difference in comparison with the diabetic group (p<0.05). Diabetic rats also exhibited a significant increase in tissue level of malondialdehyde (p<0.01) and TT treatment significantly reduced MDA level (p<0.01) in the diabetic group. Conclusion: TT treatment could enhance the capability of consolidation and recall in diabetic animals and could also improve spatial memory in them, partly via attenuation of lipid peroxidation in the hippocampus.
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Type of Study: Research | Subject: Special
Received: 2013/11/4 | Accepted: 2013/11/4 | Published: 2013/11/4

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