Volume 24, Issue 93 (4-2015)                   jour guilan uni med sci 2015, 24(93): 54-62 | Back to browse issues page

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Yazdani H, Soltani Tehrani B, Babaei P. Effects of Kiss Peptin13 on Spatial Memory in Streptozotocin-induced Alzheimer's Disease (AD) in Rats. jour guilan uni med sci. 2015; 24 (93) :54-62
URL: http://journal.gums.ac.ir/article-1-943-en.html
guilan university of medical sciences
Abstract:   (4024 Views)
Introduction: Experimental models mimicking the Alzheimer’s disease (AD) in humans are important for testing the novel therapeutic approaches in its treatment. Previous studies have shown that kisspeptin, a new neuropeptide can reduce the secretion of Aβ from the cultured cells. However, the involvement of kisspeptin13 in hippocampal dependent learning and memory processes has not been studied yet. Objectives :The aim of this study was to investigate the effects of kisspeptin13 on cognitive functions in Streptozotocin -induced AD in male rats. Materials and Methods: Thirty two male Wistar rats weighing (20±200) gr were divided into 4 groups: control, STZ (3mg/kg, ICV), saline+ STZ, kp(2µg, ICV)+ STZ. For induction of AD, STZ(3mg/kg) was administered bilaterally into the lateral ventricles . All rats were tested for spatial learning and memory in the morris water maze task Results: The results showed that STZ significantly impaired both acquisition and retrieval of spatial memory (p<0.05). On the other hand, animals receiving pretreatment of Kp demonstrated significant decrease in time and distance to find the platform in the training and probe test ( p=0.034). Conclusion: An icv injection of STZ resulted in a significant decline in spatial learning and memory and pre-treatment with kp can enhance spatial learning and memory. The results show that kpmight be a neuroprotective factor against AD in STZ- induced rat model.
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Type of Study: Research | Subject: Special
Received: 2015/04/20 | Accepted: 2015/04/20 | Published: 2015/04/20

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