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:: Volume 25, Number 99 (journal of Guilan University of medical Sciences 2016) ::
3 2016, 25(99): 1-9 Back to browse issues page
The Antinociceptive Effect of Humulus Lupulus Leaf Extract in Male Rats
dr B Khakpour Taleghani, S Jahan panah, dr M Rostampour, dr M M Ansar *, MSc E Mahdavi
PhD Guilan University of medical Sciences
Abstract:   (1330 Views)

Abstract

Introduction: Plants are one of the most important sources of medicines and have been considered by traditional medicine researchers. Most pain medications have side effects, nowadays, and it seems essential to find new analgesics with limited side effects.

Objective: The aim of this study was to evaluate the analgesic effect of Humulus lupulus (hops) leaf on pain in rats.

Materials and Methods: In this experimental study, male NMRI rats were divided into 18 groups, 7 in each: control (saline i.p. injection), positive control (morphine 2.5 mg.kg, s.c.), and hops extract groups (10, 25, 50 & 100 mg.kg, i.p.). LD50 of hops leaf hydro-alcoholic extract was calculated. Then, Tail flick, acute and chronic phases of formalin and writhing tests (6 groups each test) were used to assess pain. The results were analyzed using one-way ANOVA, followed by post hoc Tukey test. P<0.05 was chosen as the significance level.

Results: In the tail flick test, there was no difference between hops extract groups and controls. In the formalin test, pain was reduced in both acute and chronic phases by the extract (10, 25, 50 & 100 mg.kg) significantly (P<0.001). In writhing test, the extract reduced the number of abdominal contractions in comparison with control group significantly (P<0.001). Pain was significantly reduced by morphine in all tests (P<0.001).

Conclusion: Our results showed the antinociceptive effect of hops leaf Hydro-alcoholic extract after i.p. injection. 

Keywords: Formalin test, (Humulus Iupulus), Mice, Pain, Plant Extract
Full-Text [PDF 219 kb]   (659 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/10/10 | Accepted: 2016/10/10 | Published: 2016/10/10
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Khakpour Taleghani B, Jahan panah S, Rostampour M, Ansar M M, Mahdavi E. The Antinociceptive Effect of Humulus Lupulus Leaf Extract in Male Rats. 3. 2016; 25 (99) :1-9
URL: http://journal.gums.ac.ir/article-1-1268-en.html
Volume 25, Number 99 (journal of Guilan University of medical Sciences 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گیلان Journal of Guilan University of Medical Sciences

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