Volume 25, Issue 98 (7-2016)                   JGUMS 2016, 25(98): 110-116 | Back to browse issues page

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Mirmansouri A, Farzi F, Imantalab V, Khoshrang H, Biazar G, Khanjanian G et al . A Survey on the Effects of Intravenous Tranexamic Acid on the Amount of Transfusion in Patients Undergoing T.U.R-P. JGUMS 2016; 25 (98) :110-116
URL: http://journal.gums.ac.ir/article-1-1221-en.html
1- Guilan University of Medical Sciences , Farnosh_farzi@yahoo.com
Abstract:   (6788 Views)

Abstract

Introduction: Perioperative blood loss is thought to be associated with an increase in urinary fibrinolytic activity. Tranexamicacid (TXA) is a potent inhibitor of plasminogen and also urokinase activators.

Objective: To determine the efficacy of preoperative treatment with tranexamic acid in the rate of perioperative transfusions in patients undergoing transurethral resection of the prostate(TURP).

Materials and Methods: In a clinical trial, 80 patients were randomly divided into two groups: Tranexamic acid (TXA) and controls. After Spinal anesthesia with marcaine, in the Tranexamic acid group (TXA), the patients received intravenous infusion of tranexamic acid15 mg/kg before surgery and the control group received no medication, and serum Hb concentration was measured 1 hour after beginning the surgery, in recovery room, and 6 hours and 24 hours after surgery. If the hemoglobin concentration was lower than 10 mg/dL, one or more units of allogeneic packed red blood cells were transfused to keep the concentration of hemoglobin above 10 mg/dL, finally the mean need  for the erythrocyte transfusions was compared between two groups. We used statistical tests such as T-test, Repeated Measurement, ANCOVA Test and SPSS software 16. P values less than 0.05 were considered significant.

Results: This study, showed that  the mean perioperative blood transfusion  24 hours post operation, in  TXA group was less than that in control group (0.2± 0.6)vs(0.6 ±0.92).(P=0.026)

Conclusion: preoperative treatment with tranexamic acid reduces the rate of perioperative blood transfusions in patients undergoing T.U.R-P.

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Review Paper: Research | Subject: Special
Received: 2016/07/17 | Accepted: 2016/07/17 | Published: 2016/07/17

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