[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 26, Number 101 (4-2017) ::
3 2017, 26(101): 1-7 Back to browse issues page
The Genetic Association of SEP15 G1125A Polymorphism with breast Cancer
Z Salehi *, S Mohammaddoust, H Saeidi Saedi
Ph.D University of Guilan
Abstract:   (712 Views)

Introduction: A number of Single Nucleotide Polymorphisms (SNPs) in selenoprotein genes have functional consequences with regard to the expression of the proteins. Sep15 exhibits antioxidant properties and thus may be involved in the process of carcinogenesis. The best-studied polymorphism of this selenoprotein includes G1125A (rs5859) that is located in the 3’UTR in the SEP15. It is associated with G/A transition at position 1125.

Objective: To determine the association between SEP15 (G1125A) polymorphism and breast cancer risk.

Materials and methods: This control-case study comprised of two groups: 100 breast cancer patients and 120 cancer free controls. DNA was extracted from blood samples and genotyping was carried out by tetra-primer ARMS-PCR. Statistical analysis was performed using the MedCalc program (version 12.1).

Results: The distributions of GG, AG and AA Genotypes among patients were 12%, 67%, 21%, and in the controls were 9.2%, 86.6% and 4.2%, respectively. The genotype frequencies were significantly different between cases and the controls. The individuals carrying the AA genotype had a greater risk for BC compared with GG genotype (OR=3.85; 95%CI, 1.07-13.75; p=0.03).

Conclusion: This study indicates that SEP15 G1125A polymorphism may be associated with BC, and that the AA genotype may be a risk factor for the disease. However, further researches are needed to confirm the results.

Conflict of interest: none declared

Keywords: Polymorphism, Breast cancer, Selenoproteins
Full-Text [PDF 262 kb]   (300 Downloads)    
Type of Study: Research | Subject: Special
Received: 2017/04/26 | Accepted: 2017/04/26 | Published: 2017/04/26
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Salehi Z, Mohammaddoust S, Saeidi Saedi H. The Genetic Association of SEP15 G1125A Polymorphism with breast Cancer. 3. 2017; 26 (101) :1-7
URL: http://journal.gums.ac.ir/article-1-1393-en.html
Volume 26, Number 101 (4-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی گیلان Journal of Guilan University of Medical Sciences

The journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Persian site map - English site map - Created in 0.145 seconds with 814 queries by yektaweb 3430