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:: Volume 27, Issue 105 (4-2018) ::
jour guilan uni med sci 2018, 27(105): 43-49 Back to browse issues page
Inhibitory Effects of Various Concentrations of Tetracycline and Trimethoprim on the Prevention of Congenital listeriosis in Balb/C mice
Abstract:   (507 Views)
Introduction: Listeriosis is among the diseases occurring to humans, wild and domestic animals. Listeria monocytogenes, the etiologic agent of this disease, is one the most important food-borne pathogens. Given the limited information regarding the effects of various concentrations of different antibiotics on Listeria monocytogenes for in vivo studies, this study is designed.
Objective: The aim of this study was to evaluate the inhibitory effects of different concentrations of tetracycline and trimethoprim on the prevention of congenital listeriosis in Balb/C mice.
Materials and Methods: In this experimental-analytical study, the effect of various concentrations of tetracycline and trimethoprim on congenital listeriosis was evaluated in 4 groups of modelBalb/C mice, (treated with tetracycline, treated with trimethoprim, positive control and negative control). Minimum inhibitory concentration for Listeria monocytogenes was determinedin Muller-Hinton broth medium.For in vivo study, different dosages of tetracycline and trimethoprim were administered orally. Clinical evidence, sampling and culture methods were used for listeriosis identification.
Results: The obtained results showed that the percentage of live birth was higher in the treated mice than in the control groups. Using tetracycline and trimethoprim prevented abortion in treated Balb/C mice. For Trimethoprim and Tetracycline were effective for 100% and 74% prevention in abortion, respectively, as observed.
Conclusion: Based on the results obtained in this study, it can be concluded thattrimethoprim antibiotic had more inhibitory effects than tetracycline on the abortion prevention in Balb/C mice.
Conflict of interest: non declared
Keywords: Listeriosis Mice Tetracycline Trimethoprim
Full-Text [PDF 194 kb]   (89 Downloads)    
Type of Study: Research | Subject: Special
Received: 2018/04/22 | Accepted: 2018/04/22 | Published: 2018/04/22
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Inhibitory Effects of Various Concentrations of Tetracycline and Trimethoprim on the Prevention of Congenital listeriosis in Balb/C mice. jour guilan uni med sci. 2018; 27 (105) :43-49
URL: http://journal.gums.ac.ir/article-1-1611-en.html


Volume 27, Issue 105 (4-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی گیلان Journal of Guilan University of Medical Sciences

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