Volume 27, Issue 106 (7-2018)                   jour guilan uni med sci 2018, 27(106): 54-64 | Back to browse issues page

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Darbandi N, Tajiani M, Momeni H R. Effect of N -acetyl-Cysteine on Serum Oxidative Stress Factors, lipid Particles and Glucose in Streptozotocin-Induced Alzheimeric Male Rats. jour guilan uni med sci. 2018; 27 (106) :54-64
URL: http://journal.gums.ac.ir/article-1-1662-en.html
Abstract:   (1680 Views)
Introduction: Alzheimer’s disease is a progressive degenerative disease which causes memory disorders, decreases cognitive func tions and behavioural changes. Some studies have indicated that antioxidants have a positive effect on the reduction of neuronal dam age disorders in the brain.
Objective: In this study, the effects of N -acetyl-cysteine as a potent antioxidant on serum oxidative stress factors in Streptozotocin-induced Alzheimeric male rats were investigated.
Materials and Methods: In this experimental study, 24 rats were divided into 4 groups; divided into four groups (n=8): Saline, Streptozotocin) STZ(, Streptozotocin in combination with N-acetyl-cysteine(NAC) and NAC alone. Intracerebroventricular administrations of STZ (3mg/kg) on the first and the third day of the surgery and Intraperitoneally administrations of saline(ml/kg) or NAC(300mg/kg) on the fourth day after the surgery was performed. The animals’ memory was evaluated through passive task and Blood serums were used to measure the levels of malondialdehyde, total antioxidant, superoxide dismutase, glucose and lipid particles.
Results: STZ significantly reduced memory retrieval (p<0/001), decreased levels of total antioxidant (p<0/001) and superoxide dismutase (p<0/001) and increased lipid peroxidation level (p<0/001), compared with that in the control group. But no significant effect on Glucose level and lipid serum particles was observed, compared with the control group (p>0/05). Administration of NAC improved memory retrieval (p<0/001). The administration of NAC alone didn’t have cause any significant difference, compared to the control group (p>0/05). Also, the injection of NAC led to decreased levels of glucose (p<0/05), Triglyceride (p<0/001), LDL(p<0/001) and increased HDL(p<0/01) compared with the control group.
Conclusion: It seems that NAC because of its antioxidant properties can reduce effect of memory impairment induced by STZ and it can be effective in prevention and treatment neurodegenerative diseases including Alzheimer disease by modulating some risk factors such as glucose, lipid particle and reducing of oxidative stress.
Conflict of interest: non declared
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Type of Study: Research | Subject: Special
Received: 2018/07/8 | Accepted: 2018/07/8 | Published: 2018/07/8

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