Volume 17, Issue 65 (4-2008)                   jour guilan uni med sci 2008, 17(65): 108-116 | Back to browse issues page

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Abstract:   (8865 Views)
Abstract Introduction: Low grade chronic inflammation can predict persons with risk of coronary heart disease (CHD) and type 2 diabetes. Women with Poly cystic ovarian syndrome (PCOS) are insulin resistant and have high risk for CHD and type 2 diabetes. Objective: Evaluate the correlation between low grade chronic inflammation and PCOS. Materials and Methods: This case-control study was done on 27 women with PCOS who were defined base on irregular menstruation and elevated androgen (clinical hyperandrogenism or hyperandrogenemia) and 27 healthy women who were matched as a control group base on similar body mass index (BMI) and age. CRP, ESR, SHBG and Testosterone were measured in all women in both groups. Determine of insulin resistance was assessed by estimation the ratio of FBS/ to Fasting insulin. The mean of testosterone, SHBG, CRP, ESR and the ratio of FBS/ to Fasting Insulin in the two groups were compared by t- test and the correlation between BMI, testosterone, SHBG and ratio of FBS/ to fasting insulin with CRP and ESR were analyzed by Pearson correlation coefficient. Results: The finding showed: the mean of CRP was significantly difference in two groups and it was more in case group. (549/67 ± 378/38 & 2566 ± 10/22, P<0/001). The mean of ESR was 14/85 ± 12/22 and 7/74 ± 3/6 in case & control groups respectively and there was significant difference between them (P<0/007). Also, there were significantly relation between log CRP and log ESR with BMI, there were a reversed significant relation between them and SHBG. There wasn’t any relationship between log CRP & log ESR with testosteron. The collorate with FBS/Fasting Insulin and log CRP was significant and with log ESR was no significant. Conclusion: This study indicated that level of CRP and ESR in patients is higher than control group. It seems that low grade of chronic inflammation is a contributer factor to increase risk of CHD and type2 diabetes.
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Type of Study: Research | Subject: Special
Received: 2013/12/22 | Accepted: 2013/12/22 | Published: 2013/12/22