Volume 15, Issue 60 (1-2007)                   jour guilan uni med sci 2007, 15(60): 89-94 | Back to browse issues page

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Kalantari Z, Jafari H. Survey of Extract of White Cabbage in Prevention and Treatment of Peptic Ulcer Caused by Aspirin in Rats. jour guilan uni med sci. 2007; 15 (60) :89-94
URL: http://journal.gums.ac.ir/article-1-436-en.html
Abstract:   (7418 Views)
Abstract Introduction: Peptic ulcer is a multifactor trend caused by blood vessels alterations, mucus secretion, and gastric acid biochemistric condition of gastrointestinal tract. Aspirin (non-steroidal anti inflammation) with high curative effects can lead to mucus lesions in stomach. The lesion is caused by delay in stomach mucus rebuilding, increased free radicals and prostaglandin ( ) producing prohibition. There were different applications for white cabbage mentioned in traditional medicine, however the most important one was its use in digestive pains. Objective: The goal of this study was to examine the effect of extract of white cabbage in prevention and treatment of peptic ulcer caused by Aspirin in rats. Materials and Methods: In this research 48 rats were kept hungry for 48 hours and as a result ulcer peptide appeared with aspirin suspension in standard condition. For a group of rats an hour before prescribing aspirin, different amounts of edible extracts of white cabbage were used. For the other group of rats the same were used but this time after prescribing aspirin. In both conditions, animal's stomach were brought out and opened through the large curvature and lesion signs were assessed according to J. score criterion. Then statistical analyses were preformed using variation factor and T. student test by SPSS software. Results: Findings showed that white cabbage's extract in the amount of 100 mg/kg is most effective on prevention of peptic ulcer caused by aspirin (P<0.01) as compared with 200mg/kg dose used to cure peptic ulcer (P<0.05). Conclusion: As an overall conclusion, white cabbage can be used in prevention and treatment of peptic ulcer especially as prevention. Maybe the effect of this plant on peptic ulcer is like the prostaglandin that prohibits acid secretion, stimulates sodium bicarbonate and changes the PH of stomach and this can be further studied by researchers.
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Type of Study: Research | Subject: Special
Received: 2014/01/12 | Accepted: 2014/01/12 | Published: 2014/01/12

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