Volume 15, Issue 59 (10-2006)                   jour guilan uni med sci 2006, 15(59): 1-7 | Back to browse issues page

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Amiri I, Nasiri E, Mahmodi R. The effect of Vitamin E in Prevention of Developmental Defects of Diabetic Rats Embryos. jour guilan uni med sci. 2006; 15 (59) :1-7
URL: http://journal.gums.ac.ir/article-1-440-en.html
Abstract:   (5659 Views)
Abstract Introduction: Now days it is proven that maternal hyperglycemia increases production of free radicals and decreases antioxidants in the embryonic cells and through this it injures the embryos of diabetic mothers. Therefore it seems that use of antioxidants can decrease deleterious effects of hyperglycemia on embryos. Objective: This study aims to investigate the effect of vitamin E in control of embryonic developmental disorders in diabetic rats. Materials and Methods: In this experimental study, diabetes was induced by intraperitoneal injection of 65-mg/kg streptozotocin in Wister female rats with 250-300g weights and was placed with healthy male rats in the same cage for mating. Then they were divided into two groups. One group received 150mg/kg Vitamin E per day from the first day of pregnancy. Animals were killed on day 13 of gestation and embryos were collected and examined for number, size and incidence of malformations in cerebral hemispheres, cranial and caudal neuropors, upper and lower limb buds, otic and lens placodes using an stereomicroscope. Then, One Way ANOVA compared the means of length, number of reabsorbed and achieved embryos in three groups. The incidences of malformations in the groups were compared by Chi-Square test. Results: Findings show a significant difference between control group and experimental diabetic group when achieved and reabsorbed embryos counted. Frequencies of malformed embryos (at least one diagnosed malformation) in control group were 1% and in diabetic and treated diabetic groups were 46.3% and 11.6% respectively. Result showed that the incidence of embryonic malformation significantly decreased in diabetic rates, that received vitamin E and there was a significant difference in diabetes and treated diabetic groups (P<0.001). Conclusion: ‏The results shows that Vitamin E supplementation in early stages of pregnancy in diabetic mothers can prevent deleterious effects of diabetes.
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Type of Study: Research | Subject: Special
Received: 2014/01/13 | Accepted: 2014/01/13 | Published: 2014/01/13

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