Volume 15, Issue 59 (10-2006)                   jour guilan uni med sci 2006, 15(59): 20-25 | Back to browse issues page

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Roudbary S, Aini A. Survey Homocysteine Serum Level in CVA Ischemic Infarct Patients. jour guilan uni med sci. 2006; 15 (59) :20-25
URL: http://journal.gums.ac.ir/article-1-443-en.html
Abstract:   (4755 Views)
Abstract Introduction: Ischemic stroke has a high prevalence and is accompanied with high mortality, severe complication and high expenditure and cost. Increase awareness of risk factors can improve the prevention of stroke. Although several studies have proposed hyperhomocysteinemia as a risk factor for ischemic strike but some investigations have not confirmed this association. Objective: The aim of this study is to determine Homocysteine serum level in ischemic infarct patients in Poorsina Hospital, Rasht, from 2005 to 2006. Materials and Methods: In this descriptive study on hospitalized ischemic stroke patients according to clinical findings, imaging and R/O of exclusion criteria 200 patients were selected and their plasma homocysteine level measured at the base of paraclinical findings. History and manner of smoking have been considered. Smoking defined as ≥ 8 pack per year. Results: From total patients, 24.5% serum homosysteine level was normal ( <10µ mol/lit ), 34% mild elevation ( 10 – 14/99 µ mol/lit ), 36.5% moderate elevation (15 – 29.99 µ mol/lit), and 5% had intermediate elevation ( 30-100 µ mol/lit) and none of them was severe (> 100 µ mol/lit). 8.5% of patients were smokers. No significant statistical relationship was found between smoking & homocysteine level. ( p=0.053) Conclusion: Hyperhomocysteinemia is a risk factor for ischemic stroke and its effect is independent from smoking. Thus prescription of vitamin B groups and folat that decrease serum Hcy level may play a roll in decreasing of this risk factor.
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Type of Study: Research | Subject: Special
Received: 2014/01/13 | Accepted: 2014/01/13 | Published: 2014/01/13

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