Volume 15, Issue 57 (4-2006)                   jour guilan uni med sci 2006, 15(57): 1-7 | Back to browse issues page

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‍ Khaki A, Sohrabi Haghdoost I, Ghafari Novin M, Bazi P, Zahedi A, Azarmi Y. Survey the Effects of Ciprofloxacin on Rat Testis Tissue Considering Electron Microscopy. jour guilan uni med sci. 2006; 15 (57) :1-7
URL: http://journal.gums.ac.ir/article-1-472-en.html
Abstract:   (7616 Views)
Abstract Introduction: Ciprofloxacin is a synthetic antibacterial agent belonging to the family of Fluoroquinolones with a very broad spectrum against of microbial pathogens, especially Gram-negative infectious diseases, that has been approved in more than 100 countries world-wide. Objective: The aim of this study was planed to see determine the histopathological effects of ciprofloxacin after inducement, in rat testis. Materials and Methods: The twenty male wistar rats were selected and randomly divided into two groups control (n=10) and test (n=10). The test group was received 12.5mg/kg (PO) ciprofloxacin daily for sixty day however the control group just received plate. In sixtieth day the testis tissue of rats in both groups were removed and prepared for electron microscopy. Results: Electron microscopic studies of testis tissue slices of test group showed many changes such as: nuclei of spermatocyt I and sertoli cells and myoid were hyperchromatined. The Mitochondria of spermatogonia and spermatocyts cells in test group were vacuolated when as compared with control group. Thickness of spermatid tail in test group was increased when as compared with control group. Conclusion: There was a marked decrease in fertility index, testicular weight in experimental group as compared with control group. Since in our study ciprofloxacin had side effects on testis tissue in rat. It was suggested that using ciprofloxacin can decreasing fertility rate in human.
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Type of Study: Research | Subject: Special
Received: 2014/01/15 | Accepted: 2014/01/15 | Published: 2014/01/15

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