Volume 15, Issue 57 (4-2006)                   jour guilan uni med sci 2006, 15(57): 21-27 | Back to browse issues page

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Najafi B, Fakheri T, Fadakare sogheh G. Relationship of HER-2 With Other Clinical– Pathological Diagnostic Criteria in Breast Cancer Patients. jour guilan uni med sci. 2006; 15 (57) :21-27
URL: http://journal.gums.ac.ir/article-1-476-en.html
Abstract:   (6348 Views)
Abstract Introduction: HER-2/neu is a membrane protein and it is one of the determining prognostic factors of breast cancer. Objective: The aim of the study was to investigate the relationship between the expression of the HER-2 membrane protein and clinical- pathological parameters such as size: degree of the tumor differentiation, presence or absence of lymphovascular invasion and its relation with steroid hormone and P53 status in breast cancer patients. Materials and Methods: This descriptive study was done on 465 cases of breast cancers referred to two cancer centers in Gilan from 1980-1985. Patients’ demographic data, pathological and type of clinical therapy were gathered from their medical charts. All membrane samples taken by biopsy were embedded in paraffin and stained by hematoxylin-eosin technique and were evaluation by a semi-quantitative method of immunohisto- chemistery for HER2 protein, P53 and steroidal receptor. Results: A total of 32% of breast cancer patients had positive HER2 protein. There was a positive correlation between HER2 protein and P53 protein expression (P=0.000). There was a positive relationship between presence of HER2 protein and absence of steroid receptor with high-grade tumor (grade 3)(P=0.3) and absence of HER2 and presence of steroid receptor with low-grade tumor (grade 1) (P=0.5). There was no correlation between HER2 and lymphovascular invasion and size of tumor. Conclusion: In breast cancer patients, there is a positive correlation between presence of HER2 protein and degree of tumor differentiation and it also correlates with poor prognostic factors such as hormone receptor negativity and P53 positivity.
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Type of Study: Research | Subject: Special
Received: 2014/01/18 | Accepted: 2014/01/18 | Published: 2014/01/18

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