Volume 23, Issue 91 (10-2014)                   jour guilan uni med sci 2014, 23(91): 61-67 | Back to browse issues page

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Shafaghi A, Naghipour M, Haghani S, Amir Maafi A, Rouhi Rad M. Survey on the Eradication of Helicobacter Pylori Infection in Quadruple Therapy:Amoxicillin, Bismuth, Omeprazole and Clarithromycin. jour guilan uni med sci. 2014; 23 (91) :61-67
URL: http://journal.gums.ac.ir/article-1-814-en.html
Guilan University of Medical Sciences
Abstract:   (78649 Views)
Introduction: Helicobacter Pylori infection is one of the most common infectious diseases.It can result in chronic gastritis, peptic and duodenal ulcers, MALT lymphoma and gastric cancer. The H-pylori infection can lead to a wide range of diseases and the cost spent on the eradication is much less than the cost spent on the treatment of complications of the infection Objective: Study the efficacy of quadruple therapy (Amoxicillin, Bismuth, Omeprazole and Clarithromycin) on the eradication of Helicobacter Pylori infection. Materials and Methods: Between March 2011 and December 2011, we conducted a Quazi- experimental study on Helicobacter pylori infectious patients in Anzali. They were included after doing an endoscopy. Eight weeks after taking four-drugs regimen, Urea Breath Test was done to check the rate of eradication. Result: The majority of the patients were females (58.7 %). The most common symptoms before the treatment were flatulence (76 %) and epigastric pain (74.9 %). The eradication rate was 89.9 %. There were significant differences in all of the symptoms while the difference between gender and eradication rate was non-significant. Conclusion: Regardless of few side effects, all symptoms of the patients were treated significantly. As the eradication rate was 89.9 %, this quadruple drug regimen was effective on the eradication of the H-pylori. Conflict of interest: non declared
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Type of Study: Research | Subject: Special
Received: 2014/09/29 | Accepted: 2014/09/29 | Published: 2014/09/29

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