TY - JOUR JF - gums-med JO - JGUMS VL - 24 IS - 93 PY - 2015 Y1 - 2015/4/01 TI - Effects of Kiss Peptin13 on Spatial Memory in Streptozotocin-induced Alzheimer's Disease (AD) in Rats TT - بررسی اثرkiss peptin13 ، بر حافظه فضایی در موش‌های صحرایی دچار آلزایمر ناشی از استرپتوزوتوسین(STZ) N2 - Introduction: Experimental models mimicking the Alzheimer’s disease (AD) in humans are important for testing the novel therapeutic approaches in its treatment. Previous studies have shown that kisspeptin, a new neuropeptide can reduce the secretion of Aβ from the cultured cells. However, the involvement of kisspeptin13 in hippocampal dependent learning and memory processes has not been studied yet. Objectives :The aim of this study was to investigate the effects of kisspeptin13 on cognitive functions in Streptozotocin -induced AD in male rats. Materials and Methods: Thirty two male Wistar rats weighing (20±200) gr were divided into 4 groups: control, STZ (3mg/kg, ICV), saline+ STZ, kp(2µg, ICV)+ STZ. For induction of AD, STZ(3mg/kg) was administered bilaterally into the lateral ventricles . All rats were tested for spatial learning and memory in the morris water maze task Results: The results showed that STZ significantly impaired both acquisition and retrieval of spatial memory (p<0.05). On the other hand, animals receiving pretreatment of Kp demonstrated significant decrease in time and distance to find the platform in the training and probe test ( p=0.034). Conclusion: An icv injection of STZ resulted in a significant decline in spatial learning and memory and pre-treatment with kp can enhance spatial learning and memory. The results show that kpmight be a neuroprotective factor against AD in STZ- induced rat model. SP - 54 EP - 62 AU - Yazdani, H AU - Soltani Tehrani, B AU - Babaei, P AD - Guilan university of medical sciences KW - Alzheimer Disease KW - kisspeptin13 KW - Rat KW - learning KW - spatial memory UR - http://journal.gums.ac.ir/article-1-943-en.html ER -