@article{ author = {Nasiri, E and Soltani, M and Gazor, R and Mohammad-Ghasemi, F and Houseni, F}, title = {Effect of Formaldehyde Gas on Gonadotropins and Apoptosis of Testicular Germ Cells in Adult Rats}, abstract ={Abstract Introduction: Formaldehyde (HCHO) is a colorless gas used as a tissue fixative to preserve cadaver. New research shows formaldehyde in rats leads to an increase in plasma opioid internalized, which inhibits gonadotropin secretion and reduces Gonadotropin releasing hormone secreted from the hypothalamus. Survival of testicular germ cells is dependent on the presence of gonadotropin and its decrease leads to apoptosis of the cells. Objective: Evaluation of possible changes in gonadotropins and apoptosis of testicular germ cells in rats after formaldehyde gas exposure. Materials and Methods: This experimental study was performed on 24 male adult, 7 -week -old Albino Wistar Rats. The rats (based on exposure time) were divided equally into two experimental groups consisting of: E1(4 days a week, 2 hours daily) and E2(4 days a week, 4 hours daily) and a control group. Rats in experimental and control groups were killed under anesthetic conditions after 18 weeks. Serum concentration of FSH, LH and testosterone and apoptosis of testicular germ cells were measured by Immunoradiometric assay(IRMA) and TUNEL assay, respectively. Results: Results showed significant decrease of FSH, LH and testosterone in E2 group, in comparison with that in control group(p<0.05), while no significant difference was observed in apoptosis of testicular germ cells index in comparison with control group (p=0.31). Conclusion: Although formaldehyde gas in the above mentioned concentration and conditions led to a significant decrease of gonadotropin hormones in rats, it has no significant effect on the apoptosis of testicular germ cells. Thus, it seems that apoptosis of testicular germ cells in adult males rats isn't just related to gonadotropin hormones and other factors may be influential in this process. Conflict of interest: non declared}, Keywords = {Apoptosis, Formaldehyde, Rats, Testis, Vitamin C}, volume = {23}, Number = {89}, pages = {1-7}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-562-en.html}, eprint = {http://journal.gums.ac.ir/article-1-562-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} } @article{ author = {Rostampour, M and Aghaei, I and Soltani, B and Khakpour, B}, title = {Effect of Matricaria chamomilla Hydro-alcoholic Extract on PTZ-induced Seizure in Male Mice}, abstract ={Abstract Introduction: Regarding to chronic nature of epilepsy, side effects and resistance to chemical drugs, herbal medicine have received remarkable interest. Matricaria chamomilla is a medicinal plant that has been used as tranquilizer and anticonvulsant in traditional medicine. Objective: To determine the anticonvulsant effects of hydro-alcoholic extract of Matricaria chamomilla on PTZ-induced seizure in male rats. Materials and Methods: This experimental study was carried out on 48 NMRI albino male rats weighing 20-25g. They were divided randomly into six groups. All groups were injected intraperitoneally. The negative and positive control groups received saline (10 ml/1000g) and Phenobarbital (40 mg/kg), respectively. The four test groups received 500, 600, 800 and 1000 mg/kg of extract. In order to provoke convulsion, pentylenetetrazol (PTZ) was injected (80 mg/kg) to all groups after 45 minutes and initiation time of tonic-clonic seizures and mortality within 24 h were measured. Results: The results indicated that positive control group animals, which received Phenobarbital, were with no seizure and death. Different doses of extract delayed the initiation time of tonic-clonic seizures, in comparison with control group (saline). The delay was significant at 600 mg/kg (P< 0.05) and 800 and 1000 mg/kg (P< 0.001). Also, the extract decreased the 24 h death. This was significant at 800 and 1000 mg/kg (P<0. 01) and 600 mg/kg (P< 0.05). Conclusion: The present study showed that hydro-alcoholic extract of Matricaria chamomilla has inhibitive effect on PTZ-induced seizure in male rats. Conflict of interest: non declared}, Keywords = {Matricvia, Pentylenetetrazol, Seizures, Mice}, volume = {23}, Number = {89}, pages = {8-14}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-563-en.html}, eprint = {http://journal.gums.ac.ir/article-1-563-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} } @article{ author = {Mehrabian, F and RahbarTaramsari, M and KeshavarsMohamadian, S}, title = {Quality of services in training and medical emergency centers}, abstract ={Abstract Introduction: Promoting the quality of services in hospital emergency departments can lead to greater patient satisfaction, reduced complaints and improved health quality. To this end, understanding the strengths and weaknesses of the current status of hospital emergency departments can help improve the quality of services in the future. Objective: To evaluate the quality of health care of emergency centers of Rasht in 2013 Materials and Methods: This study was a descriptive and analytical one, carried out in 7 teaching, training centers including Razi hospital emergency departments, Poursina, Dr. Heshmat, Alzahra, Amiralmomenin, Shafa and Velayat in Rasht province. Data were collected using a questionnaire consisting of two parts with77 questions first part having 13 questions related to the in-charge information and the second part consisting of 64 questions related to structure, process and the function of emergency department. Data analysis software was SPSS18 using descriptive and inferential indicators. Hospitals with more than 90 percentage points for the process, structure and function were considered favorable, 71-90% were relatively favorable, 50-70% were at middle level and less than 50% were considered as weak. Results: Average number of active beds in the emergency department of the hospitals was 19.8. As shown, 85.72 % of the investigated emergency departments were relatively favorable and 14.28 % were favorable. Regarding distribution of human resources, Dr. Heshmat training and medical center with 88 %, in environment and facilities area, Velayat training and medical center with 99.5 %, in management affairs Poursina, Razi,Velayat and Dr. Heshmat with 94.54 percentage, in emergency department rules, Razi training and medical center with 96.3 percentage were in better situation. Average gained point in the field of educational process of training and medical centers in Rasht was 66.28%. Conclusion: Structure and function of the investigated training and medical centers of Rasht in terms of human resources, environment and facilities, managing and emergency department rules were relatively favorable and favorable and in the field of educational processes were at average level. Therefore, given the nature of emergency departments, it seems that paying more attentions to standardization, and particularly empowering of human resources are necessary. Continuous education of the physicians and nurses could be very helpful, too.}, Keywords = {Emergencies, Quality of Health Care }, volume = {23}, Number = {89}, pages = {15-21}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-564-en.html}, eprint = {http://journal.gums.ac.ir/article-1-564-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} } @article{ author = {TayefehDavalloo, R and DarabiF, F and Tavangar, M and Kazemnejadleili, E and Safarpour, M}, title = {Natural Tooth Color Frequency in Patient referred to Dental school of Guilan University of Medical Sciences}, abstract ={Abstract Introduction: The awareness of the range of natural tooth color in every community can facilitate the choice of the exact color of teeth. Objective: The aim of this study was to determine the color of the upper incisor teeth in patients referred to dental school of Guilan University of Medical Sciences, Northern Iran. Materials and Methods: In total, 600 intact maxillary central incisors which had been cleaned with pumice powder were selected and their colors were indexed in day light (Song Yong, Taiwan) by Vita shade guide. Data were analyzed by Chi-Square and Fisher Exact tests (p<0.05). Result: In this study, regardless of the age, A2 (32.5%) and A3 (29.8%) had the highest frequency of color and C2 had the lowest frequency (0.3%). There wasn’t any significant difference between men and women but there was a significant difference between the age groups (p<0.0001). Conclusion: Teeth become darker with age. A2 and A3 respectively had the highest frequency in age group of 20-29 and over 30 years.}, Keywords = {Color perception, Dentists, Esthetics- Dental}, volume = {23}, Number = {89}, pages = {22-28}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-565-en.html}, eprint = {http://journal.gums.ac.ir/article-1-565-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} } @article{ author = {Alizadeh, Y and KhoshbakhtPishkhani, M and KazemnezhadLeily, E and Khoshrang, H and Behboudi, H and Mohammadi, M.J and Bakhshi, F and Rostamnezhad, M}, title = {Factors Associated with Medical Students Tendency to Choose a Medical Specialty}, abstract ={Abstract Introduction: Specialty choices among medical students is an important Issue.Economic, social and cultural factors are influential in this respect. Objective: To determine the factors associated with Medical Students tendency Materials and Methods: This cross sectional study was conducted on all second semester, students, Extern and intern. We used census method for selecting case of study. Data were collected using a two part questionnaire consisting of demographic features and a questionnaire that was adapted from AHP and translated into Persian with validity and reliability confirmed through content validity.The data were analized by descriptive and analytical tests using SPSS 17 softwere. Results: In total, 191 medical students participated in this study. average student age was 23.07±2.81, 66.5% were women and 85.3 percent were single, 25.1 %, second semester, 29.3 %, Student, 20.9 %, Extern and 24.6 % were intern. The priorities in female participants were Dermatology,Radiology and Cardiology and in male were orthopedy ,ophtalmology and cardiology . The preference in the selection of specialization courses was for education, including the Cardiology and Neurosergury in second semesters and in Student, Extern and intern were Dermatology. Overall, dermatology (41.4%)Radiology (9.4%) and Ophthalmology (7.9%) were the most favored specialty choices. According chi-squer test, of the variables, studied military service related problems P <0/005)) and gender (P<0/002) were significantly associated with specialty choice. The most important factors in student specialty choice, were individual and economic factors .From economic factors, labor market (2.91 ± 1.04) and between individual factors, personal interest (3.39 ± 0.86) were the most associated factors with specialty choice (P<0/0001). Followed by other factors, including future revenues from economic factors and occupational factors, was private job after graduation from college. Among all of the relevant factors, economic factors, (p<0/0001), were the most important ones. Conclusion: Personal interest and future earning were the most important factors and dermatology ,radiology and ophtalmology were the most favored specialty Choices among Guilan University of Medical Sciences students Therefore, these factors should be considered by the respective authorities when choosing the field and plan to develop praograms for the graduates.}, Keywords = {Specialties- Medical, Students- Medical }, volume = {23}, Number = {89}, pages = {29-36}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-566-en.html}, eprint = {http://journal.gums.ac.ir/article-1-566-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} } @article{ author = {Ettehad, H and Mirbolook, M.R and Kazemnejhadleili, E and Hosseini, S.Z and Mousavi, M.S and Saghary, S}, title = {Evaluation Of Malnourished Patients in Orthopedic Ward}, abstract ={Abstract Introduction: Malnutrition is the cause of many problems in orthopedic patients. In this study, we aimed to determine the prevalence of malnutrition in patients who were hospitalized for ten days. Objective:Control the potential damage caused by malnutrition in orthopedic patients Materials and Methods: This is a cross-sectional study in which the prevalence of malnutrition in patients admitted to the Poursina hospital during the year 2011 was determined. A researcher -made questionnaire was formulated for each patient and their features were recorded on the first day of hospitalization, then, on the same day and the tenth day of hospitalization in these patients by nutritional tests, and lymphocyte count and serum albumin levels, were evaluated as well. Upon data collection, they were entered into SPSS version 16. Results: Of the 377 patients admitted to the orthopedic ward on the first day, 99 patients with malnutrition were recorded that reached to 81 cases on the tenth day. Malnutrition rate in open fractures increased in day 10 of hospitalization but reduced during the same period in closed fractures (P<0,005). Most of the malnourished patients had fracture of the femur. In patients with fractures of the femur, pelvis and multiple injuries, unlike other fracture sites, an increased incidence or severity of malnutrition during 10 days hospitalization was seen. Conclusion: Due to the negative impact of malnutrition on patient improvement and orthopedic complications, dietary control is essential in these patients.}, Keywords = {Inpatients, Malnutrition, Orthopedics }, volume = {23}, Number = {89}, pages = {37-44}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-567-en.html}, eprint = {http://journal.gums.ac.ir/article-1-567-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} } @article{ author = {Motazakker, M and ShokatNagadeh, M and Khalili, F and Shayeri, B}, title = {Hepatitis B Virus Infection among Pregnant Women Attending Health Care Centers of Urmia}, abstract ={Abstract Introduction: Viral hepatitis during pregnancy is associated with high risk of maternal complications. No data are available on hepatitis B virus (HBV) prevalence in pregnant women in north west of Iran. Objective: The aim of this study was to determine the prevalence of HBsAg in women attending health care centers of Urmia. Materials and Methods: This was a cross-sectional study that included 368 pregnant women who attended the antenatal clinics of Urmia health care centers, during the period of April 2010 - October 2010. Demographic and epidemiological data were collected. Samples were screened for HBsAg by ELISA. Those who were positive for HBsAg were tested for HBeAg. Results: Mean age of participants was 29.5±5 years. HBsAg was found in 3(0.8%) of 368 pregnant women. HBeAg was not detected in positive samples. History of abortion was reported in eighteen percent (66) of the participants. We found no significant association between HBsAg positivity and place of residence (urban or rural), age, educational level and history of abortion. Conclusion: Our results demonstrate a low prevalence of HBV infection among pregnant women in Urmia district. Prevalence of HBV infection in pregnant women has been decreased due to HBV vaccination program in last twenty years. HBsAg screening of pregnant women can decrease vertical transmission of virus from mother to child. Conflict of interest: non declared}, Keywords = {Heptitis B virus, Pregnant Women}, volume = {23}, Number = {89}, pages = {45-50}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-568-en.html}, eprint = {http://journal.gums.ac.ir/article-1-568-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} } @article{ author = {Ettehad, H and Asadi, K and Mirbolook, M.R and Soleimanha, M and Adeli, A and HaghparastGhadimLimudahi, Z and Mousavi, M.S and Saghary, S}, title = {Evaluation of 25- hydroxy Vitamin D Blood Levels in Patients with Musculoskeletal Pain}, abstract ={Abstract Introduction: Low blood levels of vitamin D in different communities is common. In this study , we evaluated the blood levels of 25-hydroxy vitamin D in patients presented with musculoskeletal pain. Objective: Evaluation of 25- hydroxy Vitamin D Blood Levels in Patients with Musculoskeletal Pain Materials and Methods: In a descriptive study, blood levels of vitamin D in 358 patients with musculoskeletal pain, that presented to the orthopedic clinic of Poorsina Hospital of Rasht during 2007-2008 years, were measured by serum levels of 25- hydroxy vitamin D using Radio Immunoassay (RIA).Normal range of vitamin D in this study, was 32 -100 ngr/milt. Amounts between 15 -32 ngr/milt, was introduced as mild vitamin D deficiency and amounts lower than 15 ngr/milt as severe vitamin D deficiency. Results: Normal range of vitamin D was seen in 65 cases (16.68%), severe vitamin D deficiency in 182 cases (51. 96%) and mild vitamin D deficiency in 107 cases (29.89%). Average serum levels of vitamin D among all cases, was 20.1ngr/milt. Severe vitamin D deficiency belong to the patients with musculoskeletal pain in the ages younger than 20 years, compared to other ages and only 4% of them had normal range of this vitamin. Conclusion: Given vitamin D severe deficiency in (51.96%), i.e., majority of cases who were studied, there seems to be a significant association between vitamin D levels and risk of musculoskeletal disorders.}, Keywords = {Musculoskeletal, pain, Vitamin D Deficiency}, volume = {23}, Number = {89}, pages = {51-56}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-569-en.html}, eprint = {http://journal.gums.ac.ir/article-1-569-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} } @article{ author = {Farrokhi, M and ShirzadSiboni, M and Tajasosi, S and Naeimi-Joben, M}, title = {Removal of hexavalent chromium Cr (VI) from Aqueous Solution using Adsorption onto Modified alder Sawdust: A Study of Equilibrium and Kinetics}, abstract ={bstract Introduction: A huge volume of wastewater from household, agriculture and industrial sources is released into the environment, which contains high level concentration of organic and inorganic materials such as hydrocarbonic solvents, heavy metals, insecticides and dyes. Heavy metals are one of the most important pollutants discharged by industries such as the electroplating and have adverse effects on environment and human health. Heavy metals such as chromium are found in plating wastewater and is harmful for human health and environment. Objective:The purpose of present study was to investigate the adsorption of heavy metals such as chromium onto modified alder sawdust by formaldehyde, sulfuric acid and sodium bicarbonate, as a cheaper adsorbent. Materials and Methods: This research was an experimental-laboratory type which investigated the removal of hexavalent chromium from aqueous solution by using modified alder sawdust with variation contact time, initial Cr(VI) concentrations pH and adsorbent dose in batch system, the residual Cr(VI) concentration was analyzed by 1,5-diphenylcarbazide method by a spectrophotometer at a wavelength of 540 nm. Then, the results were analyzed by Excel software. Results: Results showed the removal efficiency was decreased by increasing of pH and initial chromium concentration. Also, the results showed the removal efficiency was increased by increasing of adsorbent dose and contact time. Experimental isotherms and kinetic models were assessed by pseudo-first-order and pseudo-second-order kinetics and Langmuir and Freundlich isotherms models. The results show that the data were explained acceptably by pseudo-second-order kinetics and Langmuir isotherms models, respectively. Conclusion: The results showed that the removal of hexavalent chromium from aqueous solution can be done by using modified alder sawdust, both at lower cost and more effectively.}, Keywords = {Adsorption, Chromium, Kinetics, Sawdust, Hexavalent Chromium, Kinetic Models, Isotherm Models}, volume = {23}, Number = {89}, pages = {57-65}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-570-en.html}, eprint = {http://journal.gums.ac.ir/article-1-570-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} } @article{ author = {Nemati, SH and Nasiri, M and Medghalchi, A.R and Rouhi, R and Nasiri, M}, title = {Comparison of Endonasal Endoscopic versus External Dacryocystorhinostomy Results for Adult Patients with Acquired Nasolacrimal Duct Obstruction}, abstract ={Abstract Introduction: Epiphora is one of the most common complaints of the patients referred to ophthalmology clinics and primary nasolacrimal duct obstruction is the main respective cause in adults. Dacryocystorhinostomy (DCR) is the surgical treatment of epiphora that can be done by two basic methods: external and endonasal (Microscopic or Endoscopic), and the endoscopic method is minimally invasive and without scar on the face. Objective: To compare the results and complications of these two methods in treatment of the patients with primary nasolacrimal duct obstruction. Materials and Methods: This cross sectional case control study was performed in Amir-al-Momenin university Hospital of Rasht, Iran during 2008-10. Ninety-one patients (88 women and 3 men) were recruited in two groups: external (N= 46) and endoscopic DCR (N= 45). After surgery, all the patients were followed for 6-12 month periods and results and complications were studied in each group. Surgery failure was defined as: no marked improvement in tearing or any episode of postoperative dacryocystitis, postoperative nasal endoscopy with scarring in the intranasal osteotomy, and no visualization of fluorescein dye in nasal endoscopy of the participants. Also, two groups were compared in the average time of fluorescein excretion into the nose. Results were analyzed using SPSS 17 software, and the level of significance was set at 0.05. Results: Success was achieved in 92.3% of all patients, 93.5% in the external group and 91.1% in the endoscopic group (P= 0.672). The average visual analogue scale (VAS) score for subjective improvement of epiphoria in both external and endoscopic DCR groups was 8. The mean time of excretion of fluorescein dye into the nose in external and endoscopic groups were 21.3 ± 26.7 seconds and 10.4 ± 12.1 seconds, respectively (P= 0.05). Conclusion: Endonasal endoscopic DCR has comparable success rates with external DCR, and it seems that the pump function of lacrimal sac is better saved in endoscopic method, meanwhile,the loss of scar and minimal surgical invasion and complicatios are other advantages of this method over the other.}, Keywords = {Dacryocystorhinostomy (DCR), Endonasal, Endoscopic, External, Success}, volume = {23}, Number = {89}, pages = {66-74}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-571-en.html}, eprint = {http://journal.gums.ac.ir/article-1-571-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} } @article{ author = {Saberi, A and BakhshayeshEghbali, B and Kazemnezhad, E and Hosseininezhad, M and Mahdavi, F}, title = {Prevalence of Cervicogenic Headache and Associated Factors among the Patients with Chronic Headache}, abstract ={Abstract Introduction: Cervicogenic headache is a kind of chronic headache that originates from the bony structures or soft tissues of the neck and is characterized by unilateral headache and lasts from hours to weeks, which can spread to the fronto-temporal and preorbital areas. So far, there has been no exact statistics of prevalence of the cervicogenic headache in Guilan Province. Objective: To determination the relative frequency of cervicogenic headache and its relative factors among patients with chronic headache Materials and Methods: In this descriptive study, the patients’ files, referred to Neurology clinic of Guilan University of Medical Sciences from March 2010 until September 2012 with complaints of chronic headache, were assessed. We used cervicogenic headache international study group diagnostic criteria for diagnosis of cervicogenic headache. The data were recorded in the special form of information and the relative frequency of cervicogenic headache was determined among them. Independent t-Test, Chi Square and Fisher’s Exact test in SPSS software version 18, were used to analyze data. Results: Among 174 patients with chronic headache, a total of 69 patients were identified with cervicogenic headache (39.7%). The mean age of all patients was 40±13.8 years, those with cervicogenic headache were 14.4±46.5 years and those with non-cervicogenic headache were 36.2±11.7years old (P= 0.0001). Gender distribution was similar in both groups. The mean of headache duration was 34.5±21.9 hours in each episode of headache. As revealed, 95.7% of the patients with cervicogenic headache had neck pain. Conclusion: Cervicogenic headache is prevalent among chronic headaches, but it is almost always ignored whereas early diagnosis and treatment can reduce the expensive course of treatment and disability that accompanies this challenging disorder.}, Keywords = {Headache- Etiology, Cervicogenic headache }, volume = {23}, Number = {89}, pages = {74-82}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-572-en.html}, eprint = {http://journal.gums.ac.ir/article-1-572-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} } @article{ author = {Koohmanaee, SH and Taghavi, Z}, title = {Mucopolysaccharidosis VI, a Case Report}, abstract ={Abstract Introduction: Mucopolysacharidosis VI (MPS VI) is an autosomal recessive disorder in which because of deficiency of Aryl Sulfatase B, lysosomal storage disease and accumulation of abnormal metabolites in various tissues of the body are resulted. This has not been reported yet in Guilan province and is such a rare disease that can have different clinical manifestations in the range of mild to severe. Case history: In this study, a case with first compliant of suspicious movements to seizure, with 20 month of age was hospitalized and presented. The patient is a 22month year old boy with features of frontal bossing, short neck, coarse appearance, and large tongue, Mongolian spot on the back, hemangioma on buttock, dulicocephaly and lumbar kyphosis. In laboratory data evaluation, chromatography of carbohydrate and amino acid in urine and blood were normal but Aryl Sulfatase B enzyme was decreased. In radiographic evaluation, there was multiple bony abnormality reported and in differential diagnosis with types of Mucopolysacharidosis, type VI or Martoteaux-Lamy syndrome was discussed. Conclusion: As, ontime diagnosis and appropriate treatment could decrease complications of this disease such as mortality rate it seems that after observing symptoms, further investigations are mandatory}, Keywords = {Arylsufatase B, Maroteaux- Lamy Syndrome, Mucopolysaccharidosis VI }, volume = {23}, Number = {89}, pages = {83-89}, publisher = {}, url = {http://journal.gums.ac.ir/article-1-573-en.html}, eprint = {http://journal.gums.ac.ir/article-1-573-en.pdf}, journal = {Journal of Guilan University of Medical Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2014} }