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Abstract Introduction: Diabetes mellitus is accompanied with a higher incidence of cardiovascular disorders and atherosclerosis. With regard to antidiabetic potential of derivatives of Allium latifolium (AL), the effect of oral administration of this plant on the contractile reactivity of isolated aorta in diabetic rats was investigated during 6 weeks. Objective: Survey the Effect of Feeding of Allium Latifolium on Contractile Reactivity of Aorta of Diabetic rats. Materials and Methods: In this study male wistar rats (n=32) were randomly divided into 4 groups, i.e. control, AL-treated control, diabetic, and AL-treated diabetic groups. For induction of diabetes, streptozotocin (60 mg/kg i.p.) was used. The treatment groups received oral administration of plant-mixed standard pelleted food (6.25%) for 6 weeks. After 6 weeks, contractile reactivity of aortic rings to KCl and nor adrenaline was determined by using isolated tissue setup. Results: Serum glucose level in diabetic group increased during 6 weeks after the experiment as compared with one week before the study (p<0.001) AL treatment of diabetic rats showed a significant hypoglycemic effect (p<0.01). In addition, the latter group showed a lower contraction to KCl (P<0.05) and nor adrenaline (P<0.01) as compared with diabetic group. Meanwhile, there was no significant difference between control and AL-treated control groups regarding contractile reactivity. Conclusion: use of Oral administration of AL for 6 weeks can attenuate the contractile responsiveness of the vascular system and this may prevent the development of hypertension in diabetic rats.

Keywords: Aortic disorders, Diabetes mellitus, medicinal plants, Rats

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