Mirbolouk F, Salari A, Rezaei Danesh M, Kazemnejad E, Shad B, Kheirkhah J, et al . Relationship of Plasma Homocysteine Levels and Severity of Coronary Artery Disease in Patients Undergoing Coronary Angiography . JGUMS 2015; 24 (S2) :57-66
URL:
http://journal.gums.ac.ir/article-1-1059-en.html
1- Guilan University of Medical Sciences
Abstract: (7398 Views)
Abstract Introduction: Coronary Artery Disease (CAD) is rather common causes of morbidity and mortality worldwide. Recognition of its various risk factors is important to planning effective preventive measures. Hyperhomocysteinemia has been related to an increased risk of cardiovascular disease in several studies. Due to differences in nutritional patterns and genetic background among different countries, we evaluated the role of hyperhomocysteinemia as a CAD, risk factor in Iranian population. Objective: Evaluating the Relationship Between Plasma Homocysteine Levels and Severity of Coronary Artery Disease in Patients Undergoing Coronary Angiography Materials and Methods: The relation between homocysteine and the extent of CAD, measured by an angiographic score, was determined. A total of 168 patients referred for coronary angiography for clinical reasons were included. Blood samples were collected for measuring serum levels of Homocysteine. Severity of CAD determined by Gensini score. Results: CAD was found in 153 (91%) patients and 15 subjects had normal or near normal arteries. 58 patients (34.5%) had hyperhomocysteinemia. Patients with a more advanced coronary score had a higher frequency of hyperhomocysteinemia and tended to have higher mean homocysteine levels. After adjustment for major risk factors, we found an independent association between hyperhomocysteinemia and CAD. (95% C.I. for odd ratio: 1.07 – 1.43) Conclusion: We conclude that hyperhomocysteinemia is independently associated with CAD, with a positive association between homocysteine level and disease severity.
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Special Received: 2015/10/17 | Accepted: 2015/10/17 | Published: 2015/10/17