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Abstract Introduction: Colorectal cancer is a major cause of cancer-related morbidity and mortality. Performance status is a concept of great importance in the care of cancer patients, used to assess the respective impact on a patients’ activity levels, ability for self- care, and ability to work. Objective: To determine the predictors of performance status in patients with colorectal cancer. Materials and Methods: In this cross-sectional study, we assessed 110 patients with colorectal cancer, referred to Razi hospital. Demographic and clinical features were collected by data collection forms and through interview with patients and review of their medical records. Performance status was assessed by KPS and ECOG Scales .The data were analyzed using Spearman Correlation , Mann-Whitney ,Kruskal-Wallis tests and Stepwise multiple linear regression at α = 0.05 using SPSSv.16 software. Results: Out of 110 patients with colorectal cancer, 41.8% were female and 58/2 % men. Mean age of the patients+ _ SD was 58.33±12.39 years. Mean of Karnofsky Performance Status and ECOG Performance Status were 87.64±9.27, 1.02±0.717 respectively .In univariate analysis, mean of KPS was found to be related with age, marriage status, living condition, complementary insurance, social support system and hospitalization numbers. Mean of ECOG performance status was related with age, marriage status, living condition, social support system, colostomy, co morbidity and hospitalization numbers. In multiple regression analysis, the predictors of KPS were age (P>0.002), marriage status (P>0.029), complementary insurance (P>0.019) and the predictors of ECOG performance status were age (P>0.001), colostomy (P>0.032) and co morbidity (P>0.041). Conclusion: The results of the present study showed the majority of patients with colorectal cancer had good performance status. Age was an important predictor of Karnofsky and ECOG performance status both in univariate and multivariate analyses. We can conclude that consideration of the predictors could be very helpful for the above-mentioned patients’ care and treatment.

Keywords: Colorectal Neoplasms, Patients, Quality of Life

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