Immunomodulation with Epigallocatechin Gallate in Injured Spinal Cord of Rats

Khalatbary, A.R; Ahmadvand, H

Volume 20, Issue 79 (10-2011) JGUMS 2011, 20(79): 1-7 | Back to browse issues page

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Khalatbary A, Ahmadvand H. Immunomodulation with Epigallocatechin Gallate in Injured Spinal Cord of Rats. JGUMS 2011; 20 (79) :1-7
URL: http://journal.gums.ac.ir/article-1-126-en.html

Immunomodulation with Epigallocatechin Gallate in Injured Spinal Cord of Rats

A.R Khalatbary ^*

¹, H Ahmadvand²

1- Mazanderan University of Medical Sciences , khalat90@yahoo.com
2- Lorestan University of Medical Sciences

Abstract: (5861 Views)

Abstract Introduction: Spinal cord injury (SCI) stimulates an immune response that causes substantial secondary damage inside the injured spinal tissue. Objective: To determine the immunomodulatory effects of epigallocatechin gallate (EGCG) on traumatized spinal cord of rats. Materials and Methods: Rats were randomly divided into three groups of 7 rats each as follows: negative control group, positive control group, and experimental group (50mg/kg EGCG, i.p., immediately after SCI). Spinal cord samples were collected 24 hours after injury and studied for immunohistochemistry of CD4, TNF-α, IL-1β, iNOS and COX-2. Results: Epigallocatechin gallate attenuated immunohistochemical expression of immune-related response criteria. Conclusion: On the basis of these findings, we propose that EGCG may be effective in protecting the rat spinal cord from secondary damage by modulating of immune responses.

Keywords: Epigallocatechin Gallate, Immunohistochemistry, Rats, Spinal Cord Injuries

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Review Paper: Research | Subject: Special
Received: 2013/11/9 | Accepted: 2013/11/9 | Published: 2013/11/9

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