Volume 8, Issue 31 And 32 (9-1999)
JGUMS 1999, 8(31 And 32): 82-87 |
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Kalantary S. The Prevalence of Hypothyroidism Mentally Retarded Patients. JGUMS 1999; 8 (31 and 32) :82-87
URL: http://journal.gums.ac.ir/article-1-1981-en.html
URL: http://journal.gums.ac.ir/article-1-1981-en.html
Abstract: (1808 Views)
ABSTRACT
The prevalence of hypothyroidism & mental developmental disturbances has been shown to be increased in iodine deficient arease. To Clarify the extent of this relation in Iran, we elected to survey 346 mentally retarded patients of Gillan Institudes. Aster filling a check list for every patient, physical examination was done & blood sample was kept for thyroid function (T3, T4, TSH Ib) measurment with commercial kits. In Patients with hypothyroidism, Thyroid scan & X. Ray of wrist for bone age was done. The Prevalence of goiter was 25% (84 patients), goiter grade I, II & III was detected in 54 (65%), 16 (19%) and 4 patients (5%) respectively. T4 concentration in 6 patients (1.7%) was reported to be lower than normal, T4 was between 2.1-3.1 mg/dl in 2 cases & 4 patients had T4 lower than 2 mg/dl. 17 patients has TSH concentration more than 5 mu/L with a majority of TSHs (59%) between 5-10 mu/L. TSH was more than 10mu/L in 7(2%) patients. 4 patients had secondary hypothyroidism so taking them into account, the prevalence of hypothyroidism was 6% (21 cases). 2 out of These 21 cases (0.57%) had congenital hypothyroidism. 9.8% (34 patients) of mental retards had Down syndrom & 5 of them (15%) were hypothyroid. The increased prevalence of hypothyroidism in this survey emphasize the necessity of neonatal screening for hypothyroidism.
The prevalence of hypothyroidism & mental developmental disturbances has been shown to be increased in iodine deficient arease. To Clarify the extent of this relation in Iran, we elected to survey 346 mentally retarded patients of Gillan Institudes. Aster filling a check list for every patient, physical examination was done & blood sample was kept for thyroid function (T3, T4, TSH Ib) measurment with commercial kits. In Patients with hypothyroidism, Thyroid scan & X. Ray of wrist for bone age was done. The Prevalence of goiter was 25% (84 patients), goiter grade I, II & III was detected in 54 (65%), 16 (19%) and 4 patients (5%) respectively. T4 concentration in 6 patients (1.7%) was reported to be lower than normal, T4 was between 2.1-3.1 mg/dl in 2 cases & 4 patients had T4 lower than 2 mg/dl. 17 patients has TSH concentration more than 5 mu/L with a majority of TSHs (59%) between 5-10 mu/L. TSH was more than 10mu/L in 7(2%) patients. 4 patients had secondary hypothyroidism so taking them into account, the prevalence of hypothyroidism was 6% (21 cases). 2 out of These 21 cases (0.57%) had congenital hypothyroidism. 9.8% (34 patients) of mental retards had Down syndrom & 5 of them (15%) were hypothyroid. The increased prevalence of hypothyroidism in this survey emphasize the necessity of neonatal screening for hypothyroidism.
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Received: 2019/04/7 | Accepted: 2019/04/7 | Published: 2019/04/7
Received: 2019/04/7 | Accepted: 2019/04/7 | Published: 2019/04/7
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