Abstract: (2245 Views)
SUMMARY
Histiocytosis X is associated with idiopathic Proliferation of histiocytes and infiltration of eosinophils in bone marrow Spleen, Liver and other Soft tissues. Clinically there are three distinct forms:
1 - Eosinophilic granuloma is the most benign and Localized form of the disease.
2- Letterer- Siwe is the most malignant, generalized and fatal form of the disease.
3- Hand- Schuller-Christian syndrome is the most Chronic and Variable form of the disease. This can be diagnosed by the following third:
a: One or more destructive foci in the bones.
b: Uni or bilateral exophthalmus.
c: Diabetes insipidus with or without other symptoms of Pituitary deficiency.
This form of disease is seen more in children but can occur in any age group.
The reported Case is a 3- Year old boy who was Presented with following Clinical Signs and symptoms: Polyuria, polydipsia and low weight.
A Skin biopsy revealed histiocytosis X (Hand - SchullerChristian) and drugs used are Vinblastine,6 MP, Prednisolone and D.D.A.V.P
Review Paper:
Research |
Subject:
Special Received: 2019/04/10 | Accepted: 2019/04/10 | Published: 2019/04/10