Volume 33, Issue 2 (In-Press 2024)
JGUMS 2024, 33(2): 0-0 |
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Research code: 99-3-56-19247
Ethics code: IR.IUMS.REC.1399.1374
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Rastegari A, Mohammadi Z, Faghihi H, Rezaei S. Preparation and evaluation of eye drop formulation based on hyaluronic acid and vitamin B12. JGUMS 2024; 33 (2)
URL: http://journal.gums.ac.ir/article-1-2631-en.html
URL: http://journal.gums.ac.ir/article-1-2631-en.html
1- Department of Pharmaceutics and Pharmaceutical nanotechnology, School of Pharmacy, Iran university of medical sciences, Tehran, Iran , rastegari.a@iums.ac.ir
2- Department of Pharmaceutics and Pharmaceutical nanotechnology, School of Pharmacy, Iran university of medical sciences, Tehran, Iran
2- Department of Pharmaceutics and Pharmaceutical nanotechnology, School of Pharmacy, Iran university of medical sciences, Tehran, Iran
Abstract: (412 Views)
Background: Dry eye disease is a common age-related disease in the world. Vitamin B12 is an essential factor in maintaining eye health and has antioxidant properties that protect the surface of the eye from damage caused by harmful factors such as reactive oxygen species. Hyaluronic acid polymer is also very similar to natural eye tears with its biocompatibility and physical properties and this polymer is one of the important components of the extracellular matrix.
Objective: Due to the lack of formulations containing the combination of vitamin B12 and hyaluronic acid in the country and appropriate effects of these two compounds for dry eyes, we decided to formulate and analyze the stability of Eye drop formulation Based on Hyaluronic acid and vitamin B12.
methods: First, the formulation of hyaluronic acid and vitamin B12 solution with borate buffer was prepared and the stability of vitamin B12 were evaluated. In the following, the physicochemical properties of the prepared formulations were evaluated and sterile ophthalmic solution was prepared from the selected formulations under aseptic conditions. Finally, by choosing the final formulation, accelerated stability was done. The results of the tests were analyzed using Graphpad prism software.
Results: Accelerated studies after six months showed that the amount of vitamin B12 and its UV absorption did not decrease, and the physicochemical properties such as solution pH, color and viscosity did not change.
Conclusion: In conclusion, according to the results, this formulation could be a good candidate for industrial production and long-term stability studies are recommended.
Objective: Due to the lack of formulations containing the combination of vitamin B12 and hyaluronic acid in the country and appropriate effects of these two compounds for dry eyes, we decided to formulate and analyze the stability of Eye drop formulation Based on Hyaluronic acid and vitamin B12.
methods: First, the formulation of hyaluronic acid and vitamin B12 solution with borate buffer was prepared and the stability of vitamin B12 were evaluated. In the following, the physicochemical properties of the prepared formulations were evaluated and sterile ophthalmic solution was prepared from the selected formulations under aseptic conditions. Finally, by choosing the final formulation, accelerated stability was done. The results of the tests were analyzed using Graphpad prism software.
Results: Accelerated studies after six months showed that the amount of vitamin B12 and its UV absorption did not decrease, and the physicochemical properties such as solution pH, color and viscosity did not change.
Conclusion: In conclusion, according to the results, this formulation could be a good candidate for industrial production and long-term stability studies are recommended.
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Received: 2023/08/16 | Accepted: 2024/02/12 | Published: 2024/06/30
Received: 2023/08/16 | Accepted: 2024/02/12 | Published: 2024/06/30
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