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Abstract Introduction: Acute Urinary Retention (AUR) related to benign prostatic hyperplasia (BPH) is an increasingly prevalent condition in men, and the presenting feature in about 25% of men undergoing prostatectomy. Objective: Eevaluate the efficacy of sildenafil for treating patients with AUR due to BPH. Materials and Methods: This is a clinical trial, randomized, double blind study. Eighty patients with AUR related to BPH randomly assigned to receive either 0.4mg tamsulosine hydrochloride and 25mg sildenafil citrate or 0.4mg tamsulosine hydrochloride and placebo. After 48hours, the catheter was removed and ability to void in each group was assessed. Data were analyzed by SPSS 10 and K 2 , T test, P<0.05 was considered significant. Results: Differences in age, prostate size and residue was not significant between two groups (p=0.791, p=0.587, p=0.364 respectively). After catheter removal 22 patients (55%) in placebo group and 32 patients (80%) in sildenafil group voided successfully (p=0.017). After 1week 19 men (47.5%) taking placebo and 28men (70%) taking sildenafil could void yet (p=0.041).The difference between two groups was statiscaly significant (p=0.041). Conclusion: Addition of sildenafil citrate to alpha-blockers is effective in successful voiding after catheter removal for AUR related to BPH. Sildenafil may be recommended for reducing the re-catheterization rate.

Keywords: Prostatic Hyperplasia, Sildenafil, Urinary Retention

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