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Abstract Introduction: According to the World Health Organization (WHO) classification Lymphoid neoplasms are categorized into 3 major groups: Hodgkin’s disease (HD) and the non-Hodgkin’s lymphomas (NHL) of B-cell or T-cell/natural killer (NK) cell origin. Few dedicated reports have been published about metabolic imaging by FDG-PET CT in different subtypes of NHL accordig to who classification.. Objective: Determine the reliability of FDG-PET-C Tin detection of different subtypes of NHL according to using the WHO classification. Materials and Methods: In a total of 164 patients with a histological proven non-Hodgkin lymphoma, FDG-PET/CT imaging was performed for staging (n=138) and restaging (n=26). FDG-uptake pattern according to different lymphoma subtypes was qualitatively evaluated Results: Distinctive FDG-uptake could reliably be seen in one site of all patients with DLBCL (n=77), mediastinal large b-cell lymphoma (n=12), mantel cell lymphoma(n=5), PTLD (n=5), anaplastic large cell (t cell) lymphoma (n=6), precursor B lymphoblastic lymphoma (n=1), plasmacytoma of sternum (n=2), splenic marginal zone lymphoma(n=1), precursor t lymphoblastic lymphoma of thymus (n=1), extranodal NK/t cell NHL NASAL type (n=3), primary cutaneous anaplastic large cell (t cell) lymphoma (n=2), angioimmuoblastic t cell lymphoma(n=1) and Burkitt lymphoma (n=2). One case of small lymphocytic lymphoma and one case of CLL were not detected by PET/CT. Evaluation of follicular lymphoma (86% positive) and MALT lymphoma (83% positive) revealed less reliable results. Conclusion: T-cell lymphomas and most B-cell lymphomas can be reliably evaluated by FDG-PET/CT imaging.

Keywords: non-Hodgkin’s lymphoma, FDG PET-CT, world health organization (WHO)

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