Volume 16, Issue 64 (1-2008)                   JGUMS 2008, 16(64): 8-15 | Back to browse issues page

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Asgharnia M, Mehrafza M, Oudi M, Aram R, Hoseeieni A. Predictive Value of FSH, LH, and Estradiol Levels in Third Day of Menstrual Cycle and the Day of HCG Injection in Intra Cytoplasmic Sperm Injection Outcome. JGUMS 2008; 16 (64) :8-15
URL: http://journal.gums.ac.ir/article-1-338-en.html
Predictive Value of FSH, LH, and Estradiol Levels in Third Day of Menstrual Cycle and the Day of HCG Injection in Intra Cytoplasmic Sperm Injection Outcome
M Asgharnia * 1, M Mehrafza , M Oudi , R Aram , A Hoseeieni
1- , dr_sh_asgharnia@yahoo.com
Abstract:   (9726 Views)
Abstract Introduction: Several methods have been developed to estimate the functional or biological age of the ovary. Survey Follicle Stimulating Hormone (FSH) is used as a means of predicting value to fertility treatments success in most of fertility clinics across the world. Objective: Predicting value of FSH, Luteinizing Hormone (LH), and Estradiol (E2) levels in third day of menstrual cycle and the day of HCG injection in follow of Intra Cytoplasmic Sperm Injection (ICSI) outcome. Materials and Methods: In this cross-sectional study we evaluated all infertile couples who referred to Mehr infertility institute between Sep. 2004 and Dec.2006 for ICSI, with male factor, tubal factor, ovulatory factor and unexplained infertility prospectively. Long protocol Controlled Ovarian Hyperstimulation (COH) was performed for all patients. Evaluated variable consisted of female and male age, duration and cause of infertility, LH and FSH levels, estradiol (E2) levels in the third day and day of HCG administration and embryo quality. Logistic regression was performed to determined associated factors with success of ICSI. An alpha error of <0.05 was considered significant for all calculations. Results: 500 patients were evaluated during study. Rate of pregnancy was 162(36.2%). The mean age of patients showed a significant influence on ICSI in pregnant women (30.9±5.4) in comparison with non pregnant (32.4±6.4). The mean duration of infertility and cause of it didn't show any significant difference in pregnant and non pregnant (P>0.05). The mean of estradiol levels in 3rd day of period and HCG injection's day and LH level weren't statistically significant between pregnant and non pregnant (P>0.05). Relations between pregnancy rate (PR) and FSH level were statistically significant (6.4±7.4 in pregnant versus non pregnant 9.2±15.4 pg/ml) (P<0.05).Multiple logistic regressions showed no significant effect of male age, duration of infertility, cause of infertility, embryo quality also esteradiol and LH levels in the outcome of IVF/ICSI (P>0.05), but there was significant relation between female age and FSH level in ICSI success (P<0.05). Conclusion: Age of female and mean of FSH level has predictive role on success of ICSI treatment.
Keywords: Estradiol, Follicle Stimulating Hormone, Luteinizing Hormone, Pregnancy, Sperm Injections-Intra cytoplasmic
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Review Paper: Research | Subject: Special
Received: 2013/12/24 | Accepted: 2013/12/24 | Published: 2013/12/24
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