Abstract Introduction: Myringotomy and Grommet insertion is one of the most common operations that occurred in the Otorhinolaryngology. The most frequent complication after this operation is Otorrhea. Several treatments are suggested for preventation of early Otorrhea. One of them is the topical antibiotic therapy. Objective: To determine the effect of topical antibiotic therapy in preventation of early otorrhea. Materials and Methods: This non controlled clinical trial study was done on 98 cases of Refractory Serous Otitis Media (196 ears) that were candidated of Myringotomy and Ventilation tube insertion. We used 3 drops of topical Cyprofloxacin in right ear and considered left ear as control. All patients were examined for Otorrhea two weeks after surgery. Results: Total Otorrhea rate was 2.04%. This rate was 0 and 4.08 percent in right and left (control) ears, respectively. This difference was not statistically significant. Conclusion: Although use of topical antibiotic therapy effect on decreasing of early Otorrhea after Grommet insertion. This difference is not statistically significant.

Keywords: Ciprofloxacin, Otitis Media- Serous, Otitis Media with Effusion, Ventilation

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