Abstract Introduction: Coronary Artery Disease (CAD) is the main cause of death in many populations, including Iranians. The best way to control CAD is to identify and modify more effective local risk factors. Objective: The aim of this study was to determine and comparison of lipids, lipoproteins and lipoprotein (a) [Lp(a)] in patients with CAD had who referred to cardiovascular research center. Materials and Methods: This cross-sectional case-control study conducted in Yazd cardiovascular research center in 2004. One hundred patients (37 females, 63 males) with CAD and 92 controls (58 females, 34 males) were investigated. The fasting plasma Total Cholesterol (TC), Triglycerides (TG), High-Density Lipoprotein Cholesterol (HDL-C), was determined by routine laboratory methods. Lp(a), apo-A1 and apo-B100 were determined by Electro Immunoassay Method. Statistical test included, t-test for comparison of lipids and U-test for comparison of Lp(a) was used in two groups. Results: TC and Low-Density Lipoprotein Cholesterol (LDL-C) in patients (227±35 and 147±40 mg/dl respectively) were higher than controls (208±54, p=0.009 and 127±39 mg/dl, p=0.002). There were not any significant differences in TG, HDL-C and apo-A1 between two groups, but apo-B100 in patients was more than(1.25±0.4 g/L) than controls (1.13±0.36 g/L, p=0.033) also Lp(a) in patients was higher(25±27 mg/dl) than controls (18.8±19.5), but differences was statistically significant only in women (p=0.016). Conclusion: Findings showed there is more relationship between high levels of cholesterol and cholesterol-rich lipoproteins with CAD and Lp(a) with CAD in women, TG is more effective risk factor for MI in our study population so these lipids and lipoproteins may be more effective local risk factors for incidence of CAD in some area of Iran.

Keywords: Coronary Disease, Lipids, Lipoprotein (a), Lipoproteins

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