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Abstract Introduction: Neural tube defects (NTD) comprise a group of congenital malformation that includes spina bifida, anencephaly and encephalocele. Pervious study has shown that the rate of NTDs is 3.12 per 1000 in Gorgan. Some studies have indicated that Zinc deficiency is one of the causative factors of NTDs. Objective: This study carried out to compare the serum Zinc level in maternal affected NTDs with healthy controls. Materials and methods: This case- control study carried out to compare the serum Zinc level in 23 mothers with affected NTDs newborns and 36 healthy controls in Dezyani Hospital in Gorgan during 2003 by spectrophotometery technique. Results: Zinc deficiency was found in 13(36.5%) of the cases and 7(19.4 %) of the controls. The logistic regression analytic showed the relation between the presence of NTDs with Zinc deficiency (OR=5.06, 95%CI: 1.51-16.99) and drug exposure during 1st trimester in mothers (OR=13.12, 95%CI: 1.31-130.97). Conclusion: Our findings indicated that maternal Zinc deficiency was thought to be one of the important factors in the NTD etiology.

Keywords: Encephalitis, Mothers, Neural Tube Defects, Spinal Dysraphism, Zinc

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