Abstract: (10217 Views)
Abstract
Introduction: Previous studies indicated that vasopressin as a neurotransmitter can have a role in modulation of anxiety reactions.
Objective: The present study was designed to evaluate the role of vasopressin as a neurotransmitter on the fear and anxiety in plus maze model.
Materials and Methods: Male albino mice (mean weight of 25-30 g) were used for these experiments. First animals were randomly divided into three control and experimental groups. Then 5-10 μg/kg vasopressin was administered to experimental group and same amount of normal saline was given to control group ten minutes before the experiment. And in order to increase their movement and curiosity, they were put inside the black wall box for 5 min. Then animals were transferred to the Plus Maze and evaluated their anxiety reaction through observing the standard index of anxiety assessment.
Results: Results indicated that injection of vasopressin in both doses reduced anxiety reaction as compared to saline group and in the test group animals have more number of entrances and spent more time in open arm (P<0.01).
Conclusion: The above results show that vasopressin plays an important role in reduction of anxiety in Plus Maze model.
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Special Received: 2014/02/8 | Accepted: 2014/02/8 | Published: 2014/02/8