Multiple sclerosis is a chronic disease from which mostly the young adults may suffer . Pathologically ,it might be distinguished by the inflammation , demyelination and sclerosis in several regions of white matter in central nervous system. In present report , I have introduced a patient who suffered from a period of Acute Mania with Psychosis after a experience of psychological stress .In the diagnostic examinations ,it was known that she suffered from Multiple Sclerosis. Although a very small part of hospital admission is related to this disease, and the occurrence of Acute Mania Syndrome with Psychosis as the initial presentation of disease might be a rare phenomenon , the higher prevalence of bipolar disorder in this disease increases the probability of the fact that such few patients might also have been seen with the bipolar syndrome presentation in the psychiatric hospitals and notices the necessity of recognition and attention to this disease in the differential diagnosis ,especially when there are inexplicable neurological signs

Keywords: Bipolar Disorders, Manic Disorders, Multiple Sclerosis

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