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Abstract Introduction: Traumatic brain injury (TBI) is a risk factor in creation of mental disorders.Therefore, psychometrhc study is necessary to provide a mental disorder screening tool in these patients. Objective: To assess the factor structure, clinical cut-off point and psychometric properties of ‎28- Itemes version for General Health Questionnaire (GHQ-28) in patients with TBI. Materials and Methods: In descriptive- longitudinal study, 238 patients (43 females and 195 males) were chosen by nonprobability and consecutive sampling method. Each of them completed modified version for GHQ-28. After 4 months pursuit 155 patients (65.1%) reffered to a psychiatrist in order to determine the nature of mental disorder due to TBI, according to structured clinical interview based on DSM-IV diagnostic criteria. Data was analyzed by ROC curve, independent T tests, factor and discrimination analysis methods, Pearson’s correlation, Cronbach's alpha coefficients and split half reliability(Spearman- Brown’s and Guttmann’s). Results: The results showed that cut off point, sensitivity, specificity and area under the curve was 16.5%, 62.2%, 60% and 0.66% respectively by using the conventional scoring method, for the Likert scoring method same values were 40.5%, 72.2%, 57.1% and 71.0 respectively. Reliability coefficients of mentioned questionnaire by Cronbach's alpha and split half reliability method, to conventional scoring method were 0.89 , 0.76 and by Likert scoring method were 0.92 , 0.81, respectively.According to factor analysis by oblique direct method, Four factors were extracted from the GHQ-28 which were named, social dysfunction, depression, physical symptoms, anxiety and insomnia respectively. The correlation coefficients among these questionnaire sub-scales and the total score founded level optimum were between 0.46 – 0.81 (P<0.0001). Conclusion: Factor analysis indicated that four major factors are the basis of Modified Version for GHQ-28 and psychometric properties implicated their capabilities for screening of mental disorders in patients with TBI.

Keywords: Brain Injury, Factor Analysis- Statistical, Mass Screening, Mental Disorders

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