Volume 5, Issue 18 And 19 (9-1996)
JGUMS 1996, 5(18 And 19): 7-11 |
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Ali-Nezhad Zanjani Z, Mohaghgheghpoor N. Influence of Severe Protien Deficiency on Immunological Memory
Responses in Mice
. JGUMS 1996; 5 (18 and 19) :7-11
URL: http://journal.gums.ac.ir/article-1-1937-en.html
URL: http://journal.gums.ac.ir/article-1-1937-en.html
Abstract: (2370 Views)
ABSTRACT:
The effect of protein deficiency on the immune response upon primary and secondary stimulation with 5×108 sheep red blood cells (SRBC) was studied in 4 groups of mice fed by diets containing 4 or 21 percent of protein.Primary and secondary immune response were assessed by quantification of direct and indirect plaque forming cells (PFC) in immune spleens and by titration of serum hemagglutinins.
Dietary protein restriction did not inhibit the capacity of these mice to elicit memory response to SRBC ,but in contrast with control groups it markedly showed decrease of IgG response in protein deficient mice during both primary and Secondary response.
Some mechanisms which may explain the differences are the effect of protein restriction on the switching IgM producing cells to IgG and effect on B cells and T cells or Cooperating in the immune response and regulatory function.
The effect of protein deficiency on the immune response upon primary and secondary stimulation with 5×108 sheep red blood cells (SRBC) was studied in 4 groups of mice fed by diets containing 4 or 21 percent of protein.Primary and secondary immune response were assessed by quantification of direct and indirect plaque forming cells (PFC) in immune spleens and by titration of serum hemagglutinins.
Dietary protein restriction did not inhibit the capacity of these mice to elicit memory response to SRBC ,but in contrast with control groups it markedly showed decrease of IgG response in protein deficient mice during both primary and Secondary response.
Some mechanisms which may explain the differences are the effect of protein restriction on the switching IgM producing cells to IgG and effect on B cells and T cells or Cooperating in the immune response and regulatory function.
Review Paper: Research |
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Received: 2019/03/13 | Accepted: 2019/03/13 | Published: 2019/03/13
Received: 2019/03/13 | Accepted: 2019/03/13 | Published: 2019/03/13
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