Volume 10, Issue 39 And 40 (9-2001)
JGUMS 2001, 10(39 And 40): 56-64 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Mansour-Ghanaei F, Foroutan H, Fallah M, Shafaghi A, Pourshams A, Ramezani N, et al . Hepatitis Viruses Seromarkers and Liver Function inGuilan Hemophiliacs. JGUMS 2001; 10 (39 and 40) :56-64
URL: http://journal.gums.ac.ir/article-1-2110-en.html
URL: http://journal.gums.ac.ir/article-1-2110-en.html
F Mansour-Ghanaei * 
, H Foroutan , MS Fallah , A Shafaghi , A Pourshams , N Ramezani , F Farzaneh , M Yousefi
, H Foroutan , MS Fallah , A Shafaghi , A Pourshams , N Ramezani , F Farzaneh , M Yousefi
Abstract: (2023 Views)
Abstract
There are some reports about hepatitis B and C Virus infection in hemophiliacs in different part of our country. We studied Guilan Province hemophiliacs to determine the frequency of hepatitis B surface antigen (HbsAg), anti hepatitis C antibody and liver function test impairments. This study was done from Feb to Apr 1999 among hemophiliacs registered in Guilan Hemophilia Society. Patients were examined for anti hepatitis C antibody (Radio immunblot assay(RIBA-II)method), hepatitis B surface antigen (Enzyme linked Immunosorbant Assay (ELIZA)) and liver function tests. 101 patients included. Mean age was 19.7 years old (Range 3-71 years old), 100 patients were male and one female. 29 patients (28.7%) had increased serum level of Alanine Aminotransfrase (ALT). 27 patient (26.7%) were HbsAg positive and 72 patient(71.3%) were Anti HCV-Ab positive. Duration of clotting factor receiving until 1376(1996) had an association with positive Anti HCV-Ab(P=0.01) but not with positive HbsAg or increased ALT. Clotting factor activity had an association with positive Anti HCV-Ab(P<0.001) and positive HbsAg (P<0.04). Frequency of positive anti HCV-Ab in who had received leophilized Factor VIII and Cryoprecipitate Factor VIII or Factor IX and Fresh Frozen Plasma (FFP) was greater than who had received only leophilized factor VIII or FFP.(P<0.01). Frequency of HbsAg positive patients was more than what we expected. Vaccination against hepatitis B virus after diagnosis of hemophilia is advised. Although Anti HCV-Ab frequency was similar to other studies, frequency of increased ALT was less. Because of high chronicity of hepatitis C Virus, diagnose and treat Anti HCV positive patients is suggested.
There are some reports about hepatitis B and C Virus infection in hemophiliacs in different part of our country. We studied Guilan Province hemophiliacs to determine the frequency of hepatitis B surface antigen (HbsAg), anti hepatitis C antibody and liver function test impairments. This study was done from Feb to Apr 1999 among hemophiliacs registered in Guilan Hemophilia Society. Patients were examined for anti hepatitis C antibody (Radio immunblot assay(RIBA-II)method), hepatitis B surface antigen (Enzyme linked Immunosorbant Assay (ELIZA)) and liver function tests. 101 patients included. Mean age was 19.7 years old (Range 3-71 years old), 100 patients were male and one female. 29 patients (28.7%) had increased serum level of Alanine Aminotransfrase (ALT). 27 patient (26.7%) were HbsAg positive and 72 patient(71.3%) were Anti HCV-Ab positive. Duration of clotting factor receiving until 1376(1996) had an association with positive Anti HCV-Ab(P=0.01) but not with positive HbsAg or increased ALT. Clotting factor activity had an association with positive Anti HCV-Ab(P<0.001) and positive HbsAg (P<0.04). Frequency of positive anti HCV-Ab in who had received leophilized Factor VIII and Cryoprecipitate Factor VIII or Factor IX and Fresh Frozen Plasma (FFP) was greater than who had received only leophilized factor VIII or FFP.(P<0.01). Frequency of HbsAg positive patients was more than what we expected. Vaccination against hepatitis B virus after diagnosis of hemophilia is advised. Although Anti HCV-Ab frequency was similar to other studies, frequency of increased ALT was less. Because of high chronicity of hepatitis C Virus, diagnose and treat Anti HCV positive patients is suggested.
Review Paper: Research |
Subject:
Special
Received: 2019/04/17 | Accepted: 2019/04/17 | Published: 2019/04/17
Received: 2019/04/17 | Accepted: 2019/04/17 | Published: 2019/04/17
| Rights and permissions | |
 | This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Contact Information
Journal of Guilan University of Medical Sciences
Journal of Guilan University of Medical Sciences P.O. Box: 41938-93345, Iran
Tel/Fax: + (98-13)33330939
Email: medjour@gums.ac.ir
URL: http://www.Journals.gums.ac.ir
