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Abstract Introduction: Hyperemesis Gravidarum(HG) is the extreme amount of nausea and vomiting during pregnancy. The incidence of this problem is between 0.3- 2%. HG is multifactorial disorder which fetal sexuality is one of them and some studies indicated the relation between HG and female fetus. Objective: Survey the relationship between the severity of hyperemesis gravidarum and fetus sexuality. Materials and Methods: All medical cases of pregnant women who referred to Alzahra hospital from 1997 to 2007 were considered as a descriptive- analytical study. Known cases of HG were selected (separated) between them. Variables such as fetal sexuality, duration of hospitalization, age, parity, pregnancy trimester, biochemical tests were extracted and analyzed with SPSS 14 and Fisher exact test. Results: Among 197 cases, 150 cases (76.14%) were selected because of their full information 80.2% of women with female fetus, stayed ≥4 days at the hospital. This amount was 33.9% in women with male fetus (p< 0.0001). Ketonuria ≥3+ (P<0.016), Hyponatremia (P<0.035), Hyperuremia (P<0.045) were 16.5 %, 41.8 %, 62.6% in the first group and this amount were 3.4%, 23.7%, and 3.61% in the second group. 84.6% of women with female fetus and 64.4% of women with male fetus hospitalized in their first trimester (p=0.006). HG was sever in 79.1% of women with female fetus and 61% of women with male fetus (p= 0.025). Conclusion: This study showed statistical relationship between fetus Sexuality and severity of HG. The severity of this problem get raised with ketonuria, Hyperuremia, Hypernatermia and hospitalization in the first trimester.

Keywords: Fetus, Hyperemesis Gravidarum, Nausea, Pregnancy

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