Volume 18, Issue 71 (10-2009)                   JGUMS 2009, 18(71): 7-12 | Back to browse issues page

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Abedinzadeh M, Rastegar K, Zarifkar A, Rafati A, Monabati A, Khakpour B. Effect of C-peptide on Cognitive Dysfunction in Type 1 Diabetic Rat. JGUMS 2009; 18 (71) :7-12
URL: http://journal.gums.ac.ir/article-1-233-en.html
1- Guilan University of Medical Science , mahmoodabedinzadeh@yahoo.com
2- Shiraz University of Medical Science
3- Guilan University of Medical Science
Abstract:   (6520 Views)
Abstract Introduction: Diabetes mellitus is a common metabolic disorder that associates with structural and functional changes in central and peripheral nervous system and progressive decline in cognitive abilities. Recent experimental and clinical data suggested that C-peptide replacement during type 1 diabetes exerts beneficial effects on diabetic rats. Objective: Determine the effect of intraperitoneal (IP) injection of c-peptide on cognitive dysfunction in type 1 diabetic rats. Materials and Methods: 24 male Sprague dawly rats (230-300 gr) used for this project divided into 3 groups: 1. control group, 2. type 1 diabetic group and 3. Diabetic group that receive C-peptide (25 nmol/kg/daily for 28 day/IP). Diabetes induced with IV injection of Streptozotocin (60mg/kg). Twenty one days after onset of diabet, behavioral tests conducted for seven days. Results: In reference memory assessment, the latency of finding platform during four days decline significantly in all groups (P<0.05). Mean escape time in diabetic group was significantly longer in comparison to other groups (P<0.05) but in comparison to diabetic group with C-peptide group, memory impairement decline significantly (P< 0.05). During three days of working memory test, the latency required for finding platform decreased significantly (P<0.05) but this time was longer in diabetic group (P<0.05). C-peptide could improve memory in diabetic group. Conclusion: C-peptide had significant role in control and inhibition of memory disorder progression.
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Review Paper: Research | Subject: Special
Received: 2013/11/19 | Accepted: 2013/11/19 | Published: 2013/11/19

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