Volume 30, Issue 4 (1-2022)                   JGUMS 2022, 30(4): 258-267 | Back to browse issues page


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Joukar F, Soufi Afshar I, Yeganeh S, Naghipour M R, Mansour-Ghanaei A, Mansour-Ghanaei F. Comparing Serum Levels of Autophagy-Related Gene 5 in People With and Without Helicobacter Pylori Infection. JGUMS 2022; 30 (4) :258-267
URL: http://journal.gums.ac.ir/article-1-2377-en.html
1- Guilan Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
2- Gastrointestinal Cancer Screening and Prevention Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3- Guilan Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. , ghanaie@yahoo.com
Abstract:   (1338 Views)
Background: Laboratory studies have shown that gastric epithelial infection cells with Helicobacter pylori (H. pylori) can increase autophagy. Disruption in this process can cause various diseases, including cancer.
Objective: This study aims to compare the serum level of Autophag -Related Gene 5 (ATG5) in individuals with and without H. pylori infection.
Methods: This case-control pilot study was conducted in 2018 on 44 individuals aged 35-50 years referred to the endoscopy ward of Razi Hospital in Rasht, Iran. Their age, gender, Body Mass Index (BMI), smoking, and symptoms were first recorded in a form. Based on Rapid Urease Test and pathology results, they included in two groups of patient (n=22) and healthy (n=22). Serum ATG5 levels were quantitatively assessed by an ELISA kit (EIAab, USA). 
Results: Most of participants (56.8%) were male, aged over 40 years (77.3%), a BMI < 25 kg/m2 (52.3%) and not smoking cigarettes (70.5%). The mean serum levels of ATG5 in individuals with and without H. pylori infections were 63.5 ± 15.4 and 57.1±18.9, respectively (P>0.05). The mean ATG5 level was higher in women than in men (P= 0.0047).
Conclusion: Serum level of ATG5 is not significantly different between people with and without H. pylori infection. Further study is recommended using a larger sample size and based on a comparing gastrointestinal lesions.
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Review Paper: Research | Subject: Special
Received: 2021/06/23 | Accepted: 2021/12/5 | Published: 2022/01/1

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