Volume 31, Issue 2 (7-2022)
JGUMS 2022, 31(2): 112-123 |
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Research code: 2416497
Ethics code: IR.IAU.SHAHROOD.REC.1396.9
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Ziaolhagh S J, Hajabutalebi N, Ardakanizadeh M, Gholami M. Effect of L-Carnitine Consumption and Endurance Training on Lung Tissue Structure Damage in Male Boldenone-Poisoned Rats. JGUMS 2022; 31 (2) :112-123
URL: http://journal.gums.ac.ir/article-1-2411-en.html
URL: http://journal.gums.ac.ir/article-1-2411-en.html
1- Department of Exercise Physiology, Shahroud Branch, Islamic Azad University, Shahroud, Semnan Province, Iran.
2- Department of Mathematics, Shahroud Branch, Islamic Azad University, Shahroud, Semnan Province, Iran.
3- Department of Sports Sciences, Faculty of Humanities Sciences, Damghan University, Damghan, Semnan Province, Iran. ,Maliheh_ardakani@yahoo.com
2- Department of Mathematics, Shahroud Branch, Islamic Azad University, Shahroud, Semnan Province, Iran.
3- Department of Sports Sciences, Faculty of Humanities Sciences, Damghan University, Damghan, Semnan Province, Iran. ,
Abstract: (975 Views)
Background: Performing endurance training and taking L-carnitine supplements is effective in improving the performance of athletes, but its effect on repairing lung damage caused by boldenone injection is still unknown.
Objective: The present study aims to assess the effect of L-carnitine consumption alone with endurance training on lung tissue structure damage in male rats poisoned with boldenone.
Methods: In this experimental study, 30 male Wistar rats (weight= 228.53±7.94 g) were randomly divided into five groups: Control, boldenone, boldenone+training, boldenone+supplementation, and boldenone+training+supplementation. Boldenone (5 mg/kg) was injected in the biceps femoris once a week, and L-carnitine supplementation (600 mg/kg) was administrated in gavage into the stomachs of animals, three days per week. The endurance training program was included running on a treadmill for 8-week, three days per week, each for 30 minutes at a speed of 12 m/min, which reached 60 minutes and 30 m/min in the final week. Histopathological changes in bronchioles and alveoli were examined using a light microscope.
Results: The weight of two groups of boldenone+supplementation, and boldenone+training+supplementation increased significantly compared to the boldenone group (P=0.005). In the boldenone+training+supplementation group, a significant improvement in bronchioles and alveoli was observed compared to the boldenone group (P=0.001).
Conclusion: It seems that performing endurance training along with L-carnitine supplementation has a great effect on reducing the destructive effects of boldenone on lung tissue.
Objective: The present study aims to assess the effect of L-carnitine consumption alone with endurance training on lung tissue structure damage in male rats poisoned with boldenone.
Methods: In this experimental study, 30 male Wistar rats (weight= 228.53±7.94 g) were randomly divided into five groups: Control, boldenone, boldenone+training, boldenone+supplementation, and boldenone+training+supplementation. Boldenone (5 mg/kg) was injected in the biceps femoris once a week, and L-carnitine supplementation (600 mg/kg) was administrated in gavage into the stomachs of animals, three days per week. The endurance training program was included running on a treadmill for 8-week, three days per week, each for 30 minutes at a speed of 12 m/min, which reached 60 minutes and 30 m/min in the final week. Histopathological changes in bronchioles and alveoli were examined using a light microscope.
Results: The weight of two groups of boldenone+supplementation, and boldenone+training+supplementation increased significantly compared to the boldenone group (P=0.005). In the boldenone+training+supplementation group, a significant improvement in bronchioles and alveoli was observed compared to the boldenone group (P=0.001).
Conclusion: It seems that performing endurance training along with L-carnitine supplementation has a great effect on reducing the destructive effects of boldenone on lung tissue.
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Received: 2021/10/7 | Accepted: 2022/05/1 | Published: 2022/07/1
Received: 2021/10/7 | Accepted: 2022/05/1 | Published: 2022/07/1
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