Volume 31, Issue 4 (1-2023)
JGUMS 2023, 31(4): 286-299 |
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Research code: IR.IAU.M.REC.1399.036
Ethics code: IR.IAU.M.REC.1399.036
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Mehboodi M, Asgharpour H, Hosseini S A, RezaeeShirazi R. The Effect of Swimming and Resveratrol on Antioxidant Markers and Lipid Peroxidation Index in Liver Tissue. JGUMS 2023; 31 (4) :286-299
URL: http://journal.gums.ac.ir/article-1-2435-en.html
URL: http://journal.gums.ac.ir/article-1-2435-en.html
1- Department of physical education and sports sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran.
2- Department of physical education and sports sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran. , mehboodimaryam@yahoo.com
3- Department of physical education and sports sciences, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
2- Department of physical education and sports sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran. , mehboodimaryam@yahoo.com
3- Department of physical education and sports sciences, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
Abstract: (760 Views)
Background Aging is associated with metabolic disorders. Although the beneficial effects of exercise and resveratrol consumption in the health of the elderly has been reported, the combined effect of intermittent swimming and resveratrol consumption on the antioxidant system in liver tissue is not clear yet.
Objective This study aims to investigate the combined effect of intermittent swimming and resveratrol consumption on the expression of superoxide dismutases (SOD), glutathione peroxidase (GPx), and Malondialdehyde (MDA) in the liver tissue of older rats.
Methods In this experimental study, 32 elder rats were divided into four groups: control, swimming, resveratrol and swimming+resveratrol. The resveratrol (100 mg) dissolved in 1% methylcellulose was administrated daily by gavage. The swimming was performed at three sessions per week. The GPx and SOD expression levels were measured by real-time polymerase chain reaction method, and the MDA level was measured by ELISA method.
Results The GPx level in the swimming+resveratrol group were significantly higher than in the control (P=0.001), resveratrol (P=0.04) and swimming (P=0.002) groups. MDA levels in the resveratrol (P=0.001), swimming (P=0.001) and swimming+resveratrol (P=0.001) groups were significantly lower than in the control group; in the swimming+resveratrol group, it was significantly lower than the resveratrol (P=0.001) and swimming (P=0.009) groups.
Conclusion It seems that intermittent swimming and resveratrol consumption have favorable effects on improving the antioxidant defense system and lipid peroxidation in liver tissue. Therefore, it is recommended to use intermittent swimming and resveratrol to prevent liver damage in the elderly.
Objective This study aims to investigate the combined effect of intermittent swimming and resveratrol consumption on the expression of superoxide dismutases (SOD), glutathione peroxidase (GPx), and Malondialdehyde (MDA) in the liver tissue of older rats.
Methods In this experimental study, 32 elder rats were divided into four groups: control, swimming, resveratrol and swimming+resveratrol. The resveratrol (100 mg) dissolved in 1% methylcellulose was administrated daily by gavage. The swimming was performed at three sessions per week. The GPx and SOD expression levels were measured by real-time polymerase chain reaction method, and the MDA level was measured by ELISA method.
Results The GPx level in the swimming+resveratrol group were significantly higher than in the control (P=0.001), resveratrol (P=0.04) and swimming (P=0.002) groups. MDA levels in the resveratrol (P=0.001), swimming (P=0.001) and swimming+resveratrol (P=0.001) groups were significantly lower than in the control group; in the swimming+resveratrol group, it was significantly lower than the resveratrol (P=0.001) and swimming (P=0.009) groups.
Conclusion It seems that intermittent swimming and resveratrol consumption have favorable effects on improving the antioxidant defense system and lipid peroxidation in liver tissue. Therefore, it is recommended to use intermittent swimming and resveratrol to prevent liver damage in the elderly.
Review Paper: Research |
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Received: 2021/12/4 | Accepted: 2022/09/21 | Published: 2022/11/16
Received: 2021/12/4 | Accepted: 2022/09/21 | Published: 2022/11/16
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