Volume 33, Issue 2 (In-Press 2024)
JGUMS 2024, 33(2): 0-0 |
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Darbandi B, Dalili S, Hakemzadeh S T, Koohmanaee S, Mohammadi M H, Baghersalimi A, et al . : Hematological Indices in Children with type 1diabetes mellitus: A Review Article. JGUMS 2024; 33 (2)
URL: http://journal.gums.ac.ir/article-1-2618-en.html
URL: http://journal.gums.ac.ir/article-1-2618-en.html
Bahram Darbandi1 
, Setila Dalili * 2, Seyede Tahoura Hakemzadeh1 , Shahin Koohmanaee1 , Mohammad Hasan Mohammadi3 , Adel Baghersalimi1 , Mercedeh Enshaei1 , Soodeh Salehi1 , Shohreh Maleknejad4
, Setila Dalili * 2, Seyede Tahoura Hakemzadeh1 , Shahin Koohmanaee1 , Mohammad Hasan Mohammadi3 , Adel Baghersalimi1 , Mercedeh Enshaei1 , Soodeh Salehi1 , Shohreh Maleknejad4
1- Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
2- Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran ,Setiladalili1346@yahoo.com
3- Department of Pediatrics, Zabol University of Medical Sciences, Zabol, Iran.
4- Pediatric Diseases Research Center, Gilan University of Medical Sciences, Rasht, Iran,
2- Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran ,
3- Department of Pediatrics, Zabol University of Medical Sciences, Zabol, Iran.
4- Pediatric Diseases Research Center, Gilan University of Medical Sciences, Rasht, Iran,
Abstract: (791 Views)
Background: Diabetes mellitus is a group of chronic metabolic diseases with increased blood sugar. In various studies, the association between diabetes and hematologic parameters has been investigated. Diabetes mellitus may lead to different hematologic abnormalities.
Objective: As complete blood cell count is more available than hemoglobin A1C, in this study we summarize the hematologic changes in diabetes type 1. The reasons and association of different changes with the prognosis will be discussed.
Methods: This study is a review article based on a search with the keywords in medical-scientific databases, including PubMed, Scopus, MEDLINE, and Google Scholar, from 2000 to 2023. All articles were evaluated, and 50 articles were selected as the primary sources of study. All valuable and widely used points are presented.
Results: The mean of RBC count, hemoglobin, and hematocrit were less in the diabetic group in comparison to healthy patients. The recent studies show an association of the anemia with development of diabetic nephropathy. Diabetic patients have less RDW, MPV, and PDW. Studies showed that patients who have recently been diagnosed with type 1 diabetes mellitus have higher leukocyte and neutrophil count. Also, there is a positive correlation between increased leukocyte and hyperglycemia.
Conclusion: The occurrence of blood cell changes in children with type 1 diabetes is related to the prognosis of the disease. Since hematological tests (complete blood cell count) are available, the use of these tests is helpful for early detection of complications.
Methods: This study is a review article based on a search with the keywords in medical-scientific databases, including PubMed, Scopus, MEDLINE, and Google Scholar, from 2000 to 2023. All articles were evaluated, and 50 articles were selected as the primary sources of study. All valuable and widely used points are presented.
Results: The mean of RBC count, hemoglobin, and hematocrit were less in the diabetic group in comparison to healthy patients. The recent studies show an association of the anemia with development of diabetic nephropathy. Diabetic patients have less RDW, MPV, and PDW. Studies showed that patients who have recently been diagnosed with type 1 diabetes mellitus have higher leukocyte and neutrophil count. Also, there is a positive correlation between increased leukocyte and hyperglycemia.
Conclusion: The occurrence of blood cell changes in children with type 1 diabetes is related to the prognosis of the disease. Since hematological tests (complete blood cell count) are available, the use of these tests is helpful for early detection of complications.
Keywords: type 1 diabetes mellitus, Hematology, white blood cells, blood platelet, Erythrocytes, pediatrics
Review Paper: Research |
Subject:
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Received: 2023/07/4 | Accepted: 2023/10/10 | Published: 2024/06/30
Received: 2023/07/4 | Accepted: 2023/10/10 | Published: 2024/06/30
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