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Abstract Introduction: Population pattern in Guilan province like other provinces in Iran represents an increasing pattern in young population. According to higher prevalence of substance use among adolescents, its negative effects on this group and paucity of previous studies this study seemed necessary. Objective: This study was performed to estimate the prevalence of substance use between high school students in Guilan 2005-2006. Materials and Methods: This is a cross-sectional and descriptive study which was performed on 1950 Guilan’s high school students. Samples were selected by cluster sampling. Variables including demographic data (sex, age, school type, birth order and parents’ education), substance use and its kind, First motive for use, Last use and usage frequency were analyzed by SPSS software and chi-square and Fisher-Exact tests. Results: 23.7% of students had at least one time substance use with considering cigarette and 12.8% had at least one time substance use without considering cigarette. Proportional frequency of substance use in males (31.3%) was more than females (14.8%) (P=0.0001). General prevalence of substance use was: Cigarette (20%), Alcohol (10.5%), Opium (2.4%), Ecstasy (2.1%), Cannabis (2%) and Heroin (0.3%). There was significant difference between Alcohol (p=0.0001), Opium (p=0.0162), Ecstasy (p=0.0081), Cannabis (0.0001) and Cigarette (p=0.0001) and sex. Higher educational levels and higher ages in boys were related to higher substance use.(p=0.0014 & p=0.0002). In addition there was significant relationship between substance use in students and cigarette use among family members (p=0.0001). Conclusion: Substance use in male students was significantly higher than females. Higher educational level and higher age in male students were related to higher substance use. In addition prevalence of substance use in students with smoker parents was higher. There weren’t any relationship between birth order and kind of school, parents’ educational level and substance use. Regarding our results we have to give special attention to adolescents especially in high school boys with higher ages and educational levels and students with smoker parents.

Keywords: Narcotics, Prevalence, Students

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