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Abstract Introduction: Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Pain in newborn induces permanent structural and functional changes, therefore effective treatment of pain is an important objective in pediatric nursing. Objective: Survey the effect of oral glucose solution on pain physiological and behavioral indices in hospitalized neonates. Materials and Methods: This was a clinical trial and double blind randomized study. According conditions of study 132 neonates (gestational age 37-42 week, postnatal age 1-7 days) were matched. The case group received 2 ml glucose 30% and control group received 2 ml water by mouth 2 minutes before arterial blood sampling. Then heart rate and O2 saturation changes were measured immediately and 10 minutes after sampling and, cry duration was measured and divided in the first 5 minutes after sampling. Data groups were compared by statistical test in two to control and treatment groups. Results: The results indicated statistically significant differences in heart rate and O2 saturation among case group as compared with the control group(p<0/001) in 5 minutes after blood sampling. Also there is significant differences among two groups between heart rate (p<0/045) and O2 saturation (p<0/001) at 10 minutes after blood sampling. Cry duration in the first 5 minutes after blood sampling were significantly reduced in treatment group (p<0/001) as compared with control group. Conclusion: Receiving 2 ml oral glucose 30% before blood sampling can reduce physiological and behavioral indices of pain in neonates.

Keywords: Glucose Solution Hypertonic, Infant- New born, Nursing care- Pain

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