Volume 22, Issue 87 (10-2013)                   JGUMS 2013, 22(87): 78-83 | Back to browse issues page

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Mehrafza M, Raoufi A, Abdollahian P, Nikpouri Z, Nasiri M, Hosseini A. Comparison of IVF Outcome in Two Groap of Patients with PCOS . JGUMS 2013; 22 (87) :78-83
URL: http://journal.gums.ac.ir/article-1-47-en.html
Comparison of IVF Outcome in Two Groap of Patients with PCOS
M Mehrafza * 1, A Raoufi2 , P Abdollahian2 , Z Nikpouri2 , M Nasiri2 , A Hosseini2
1- Infertility Research Center, Mehr Medical Center , dr_mehrafza@mehrhealthcare.com
2- Infertility Research Center, Mehr Medical Center
Abstract:   (8682 Views)
Introduction: PCOS (Polycystic ovary syndrome) patients undergoing infertility treatments present a greater sensitivity to gonadotrophins and higher incidence of OHSS when human chorionic gonadotropin (hCG) is administrated for the induction of final oocyte maturation. Lower dose of hCG can reduce the occurrence of OHSS Objectives: The aim of present study was to evaluate the effect of hCG dose reduction on IVF outcome in PCOS undergoing controlled ovarian hyperstimulation Materials and Methods: In this retrospective study, we included 39 women with PCOS who had undergone one-third dose depot GnRH agonist protocol. Ovarian stimulation was initiated with rFSH and continued by HMG. Final follicular maturation is triggered by 5000 (group A) or 10000 IU (group B) of hCG according to antral follicle count and estradiol levels. Basal and stimulation variables were analyzed between the groups. Results: There were no significant differences seen in all characteristics (Age, BMI, LH, FBS, cholesterol level, prolactin, Hirsutism, menstrual cycle, length of stimulation, E2 level on hCG day, number of total and MII oocytes, number of embryos transferred, mean transferred embryo score, OHSS, ongoing implantation rate, biochemical pregnancy rate, abortion rate, live birth rate) between the groups except for the number of GnRH ampoules. The E2 level and the number of total and metaphase II oocytes were higher in 5000 IU group. Higher rates of biochemical pregnancy, live birth and continuing pregnancy were observed in 10000 IU group. Conclusion: It seems that reduction in implantation rate and IVF outcome is related to lower dose of hCG in PCOS undergoing one-third dose depot GnRH agonist protocols. Conflict of interest: non declared
Keywords: Chorionic Gonadotropin, Human, Fertilization in Vitro, Polycystic Overy Syndrome
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Review Paper: Research | Subject: Special
Received: 2013/10/30 | Accepted: 2013/11/17 | Published: 2013/11/17
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