1. Introduction
besity and diabetes are closely related, so that type 2 diabetes often occurs with obesity. Therefore, obesity is considered the leading cause of type 2 diabetes [1]. Many researchers around the world are working to reduce the complications of diabetes using a variety of methods. Exercise is one of the most important strategies to control and treat blood glucose and hyperlipidemia and reduce the incidence of diabetes and cardiovascular complications [2, 3, 4, 5, 6, 7, 8, 9, 10]. Also, regular exercise in diabetes eliminates the severe insulin response, as the muscles and liver become accustomed to storing more glycogen. Proper exercise increases muscle mass, decreases fat mass, improves insulin resistance, and disorders caused by diabetes [11, 12, 13]. Because of the obstacles and problems associated with existing treatment and control methods, the need for new and effective treatment of diabetes is quite evident. To achieve this goal, the influential role of medicinal plants can be sought [14]. In the present study, the interactive effects of exercise and medicinal plants on lipid profile and glycemic indices were reviewed in diabetic status. The present study investigates the effects of consuming 10 herbals simultaneously with doing exercise.
2. Methods
We searched all databases, especially Web of Science, PubMed, SID, and Magiran, using keywords of “training", “exercise", “glycemic indices", “lipid profile", “medicinal plant", and “anti-diabetic component", without time limit to find the relevant articles for this study. The found articles were then categorized based on exercise and medicinal plants on carbohydrate and lipid metabolism. According to the studies found in the databases, there are 564 articles related to exercise and medicinal plants. According to the inclusion criteria (dealing with physical activity, medicinal plants, and also diabetes), 34 articles related to the effects of exercises and medicinal plants on diabetes status were selected for this study. 
Saffron 
Saffron is a plant with the scientific name of Crocus sativus L [15]. The bitter taste of saffron is due to a substance called picrocrocin. Crocin, crocetin, and safranal are the main active ingredients of saffron [16]. Researchers believe that saffron and its ingredients can induce anti-diabetic effects and metabolic regulation by increasing antioxidants [17]. It seems that one of the possible mechanisms of crocin on the improvement of diabetic disorders can be the antioxidant properties of crocin and the blood glucose and glycosylated hemoglobin reducing effects [18, 19]. Crocin can protect the unsaturated fatty acids in cell membranes by reducing cyclophosphamide-induced free radicals. 
Ginger 
Ginger, with the scientific name of Zingiber officinale from the Zingiberaceae family, is one of the medicinal plants widely used in traditional medicine [20]. This plant is used to treat diabetes [12], rheumatism, asthma, nausea, vomiting, hypertension, dementia, fever, and infection. It also has sedative and anti-anxiety properties [14]. It seems that the possible effects of ginger on hypoglycemia depend on the inhibition of hepatic glucose 6-phosphatase activity and consequently the reduction of blood glucose [12].
Cinnamon 
Cinnamon, with the scientific name of Cinnamomum verum, belongs to the Lauraceae family. It lowers blood glucose and lipid and has antioxidant, anti-inflammatory, and neuroprotective properties. Regarding the therapeutic effects of cinnamon, it has been reported that cinnamon lowers blood pressure through peroxisome-activating receptors and inhibits the formation of the final product due to glycosylation. Also, there are various phenolic agents, such as catechins, epicatechin, procyanidin B2, and phenol polymers in cinnamon, that have inhibitory effects on the formation of glycosylated end products [21].
Chamomile 
Chamomile, scientifically known as Matricaria chamomilla, is a medicinal plant that grows in many areas worldwide, including Africa, Asia, North and South America, Europe, and Australia [14]. Chamomile is rich in flavonoids and phenolic compounds that are effective antioxidants in neutralizing oxygen-free radicals. Therefore, the reduction of oxidative stress can be due to the presence of two routine and pathological compounds in this plant, which has neutralizing solid properties of free radicals. They are also potent lipoxygenase inhibitors, which is free-radical scavenger.
Aloe vera 
Aloe vera, scientifically known as Aloe vera L., belongs to the Liliaceae family and is one of the most valuable medicinal plants in the world. Aloe vera is full of various antioxidants and therefore eliminates free radicals in the body. It also contains sapotin, cinnamic acid, and salicylic acid. Aloe vera, with its high content of phenolic compounds, manganese acetyl, mannose phosphate, plays an important role in controlling free radicals in the body. Researchers have introduced a critical substance called acemannan in aloe vera gel, which is similar to glucomannan and is effective in lowering blood glucose [22].
Dill 
Dill, with the scientific name of Anethum graveolens, belongs to the Apiaceae family. Dill fruit has a similar therapeutic effect to fennel, anise, and cumin. Dill has been reported to have antibacterial, antifungal, anticonvulsant, antioxidant, and anti-cancer effects, protecting the gastric mucosa and reducing gastric acid secretion, lowering blood glucose, blood lipids, and cholesterol [23]. The hypoglycemic effects of dill extract have been suggested to be related to the flavonoid composition of quercetin. One of the possible mechanisms of action of this plant in lowering blood glucose is the effect on glucose uptake. 
Portulaca oleracea 
Portulaca oleracea is a member of the Portulacaceae family. Portulaca oleracea is a rich source of antioxidants such as vitamins A, B1, C, E, β-carotene, and other essential amino acids [24]. Portulaca oleracea has hypolipidemic and hypoglycemic properties due to its various compounds such as flavonoids, polysaccharides, and unsaturated fatty acids. Portulaca oleracea is rich in phenolic, polyphenolic, and antioxidant compounds. The most important antioxidant compounds are α-tocopherol, ascorbic acid, and glutathione. 
Coriander 
Coriander is scientifically known as Coriandrum Sativum L [25]. Coriander has been reported to release insulin and have insulin-like effects, as well as reducing insulin resistance [26]. In addition, fatty acids of coriander, such as linoleic acid, oleic acid, and ascorbic acid or vitamin C, are very effective in lowering blood cholesterol.
Fenugreek 
Fenugreek (Trigonella foenum-graecum L.) contains polyphenols, steroids, alkaloids, saponins, and amino acids. Because of its antioxidant properties, lowering blood glucose, blood lipids, and anti-inflammatory effects, it is widely used to treat diabetes and obesity. The exact mechanism of the fenugreek action on cell metabolism is not yet fully understood, but the polyphenols and saponins in fenugreek seem to play a major role in lowering blood lipid levels.
Black seed 
Black seed is scientifically known as Nigella sativa L. Black seed is used in traditional medicine in medicinal compounds used for hyperlipidemia [27]. Black seed contains fat, vitamins, minerals, proteins, and carbohydrates. The results of previous research have shown that polysaccharides, flavonoids, glycoproteins and polypeptides, steroids, alkaloids, and pectin in medicinal plants can justify the possible hypoglycemic properties of black seed [28]. 
3. Discussion and Conclusion
The two main bases of management and prevention of diabetes are diet and exercise. Regular exercise programs in people with diabetes can improve insulin function and increase muscle and liver glycogen stores. Proper exercise increases muscle mass by increasing glucose uptake, increasing insulin sensitivity, and optimal glycemic control. It seems that because of the challenging nature of the exercise intervention (depending on the intensity and type of exercise) and the potential risks of strenuous exercise, the proper diets, plant antioxidants, and physical activity can improve the metabolic indices in diabetic patients. Finally, it should be noted that in most studies on the lipid profile and glycemic-indices reducing effects of medicinal plants, their toxic effects have not been evaluated. In other words, the safety margin between therapeutic and toxic effects has not been determined. So it is recommended that besides examining the therapeutic effects of plants and their active compounds, their toxicity be investigated.

Ethical Considerations
Compliance with ethical guidelines
This article is a review article with no human or animal experimentation. No data have been manipulated to support the final result of the research, and all available studies in line with the research topic have been mentioned.

Funding
This research did not receive any grant from funding agencies in the public, commercial, or non-profit sectors. 

Conflicts of interest
The author declared no conflict of interest.


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