Volume 33, Issue 2 (In-Press 2024)
JGUMS 2024, 33(2): 0-0 |
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Research code: 2079
Ethics code: IR.GUMS>REC.1397.092
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Pourkazem S, Sharifi Rad M, Baghersalimi A, Salehi S, Enshaei M, Aminzadeh V, et al . The Effect of Iron Chelation Therapy with Deferasirox on Liver Aminotransferases Levels in Transfusion-dependent β-thalassemia Patients. JGUMS 2024; 33 (2)
URL: http://journal.gums.ac.ir/article-1-2621-en.html
URL: http://journal.gums.ac.ir/article-1-2621-en.html
Shayan Pourkazem1 
, Mohammadreza Sharifi Rad1 , Adel Baghersalimi1 , Soodeh Salehi1 , Mercedeh Enshaei1 , Vahid Aminzadeh1 , Behrang Motamed2 , Bahram Darbandi * 3
, Mohammadreza Sharifi Rad1 , Adel Baghersalimi1 , Soodeh Salehi1 , Mercedeh Enshaei1 , Vahid Aminzadeh1 , Behrang Motamed2 , Bahram Darbandi * 3
1- Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
2- Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rast, Iran
3- Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. ,darbandi45@gums.ac.ir
2- Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rast, Iran
3- Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. ,
Abstract: (483 Views)
Background: Various body tissues of β-thalassemia patients are exposed to destructive effects of iron overload due to chronic blood transfusions. Therefore, the decision to start a regular blood transfusion therapy for these patients often leads to administration of iron chelators, nowadays. Deferasirox as an orally effective iron-chelating drug could cause some therapy-related adverse events, such as increased liver enzymes and serum creatinine.
Objective: This study has evaluated the effect of deferasirox on serum levels of ferritin and liver aminotransferases in transfusion-dependent β-thalassemia patients.
Methods: In this study, changes in the serum levels of ferritin and liver aminotransferases in β-thalassemia patients receiving deferasirox, who were reffered to the thalassemia department of the 17 Shahrivar hospital and Beesat clinic in Rasht, Iran, have been evaluated, retrospectively. In this regard, 104 β-thalassemia major patients over two years of age receiving regular blood transfusions and deferasirox for at least two consecutive years were enrolled. Information of patients including age, sex, blood transfusion frequency, deferasirox administration duration and dosage, and serum levels of ferritin and liver enzymes between baseline and at least two years after iron chelation therapy with deferasirox was recorded.
Results: The decreased serum levels of ferritin (P=0.017), aspartate aminotransferase (P=0.0001) and alanine aminotransferase (P=0.015) in the last blood testing after deferasirox therapy were statistically significant. However, there was no statistical significance between the decreased serum levels of liver aminotransferases and factors including age, sex, blood transfusion frequency, duration and dosage of deferasirox administration.
Conclusion: Deferasirox revealed significant reducing effects on serum ferritin and liver aminotransferases in our study.
Objective: This study has evaluated the effect of deferasirox on serum levels of ferritin and liver aminotransferases in transfusion-dependent β-thalassemia patients.
Methods: In this study, changes in the serum levels of ferritin and liver aminotransferases in β-thalassemia patients receiving deferasirox, who were reffered to the thalassemia department of the 17 Shahrivar hospital and Beesat clinic in Rasht, Iran, have been evaluated, retrospectively. In this regard, 104 β-thalassemia major patients over two years of age receiving regular blood transfusions and deferasirox for at least two consecutive years were enrolled. Information of patients including age, sex, blood transfusion frequency, deferasirox administration duration and dosage, and serum levels of ferritin and liver enzymes between baseline and at least two years after iron chelation therapy with deferasirox was recorded.
Results: The decreased serum levels of ferritin (P=0.017), aspartate aminotransferase (P=0.0001) and alanine aminotransferase (P=0.015) in the last blood testing after deferasirox therapy were statistically significant. However, there was no statistical significance between the decreased serum levels of liver aminotransferases and factors including age, sex, blood transfusion frequency, duration and dosage of deferasirox administration.
Conclusion: Deferasirox revealed significant reducing effects on serum ferritin and liver aminotransferases in our study.
Review Paper: Research |
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Received: 2023/07/14 | Accepted: 2023/12/23 | Published: 2024/06/30
Received: 2023/07/14 | Accepted: 2023/12/23 | Published: 2024/06/30
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