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Research code: 1404-6-125-90926
Ethics code: IR.TUMS.SPH.REC.1403.162
Mahdieh Sorouri Majd1 
, Mojgan Aryaeipour1 , Eshrat Beigom Kia1 , Seyedeh Hajar Sharami2 , Mehdi Mohebali3 , Akram Sepahvand3 , Azadeh Jafari2 , Zohreh Fakhrieh-Kashan Fakhrieh Kashan *3
, Mojgan Aryaeipour1 , Eshrat Beigom Kia1 , Seyedeh Hajar Sharami2 , Mehdi Mohebali3 , Akram Sepahvand3 , Azadeh Jafari2 , Zohreh Fakhrieh-Kashan Fakhrieh Kashan *3
1- 1Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Obstetrics & Gynecology, Reproductive Health Research Center, Al-Zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3- Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Obstetrics & Gynecology, Reproductive Health Research Center, Al-Zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3- Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Abstract: (12 Views)
Background: Fascioliasis is an endemic disease in Guilan Province. Pregnant women, as a high-risk group, are susceptible to various infections, including fascioliasis, in endemic areas of Fasciola species.
Objective: This cross-sectional study evaluates the seroprevalence of fascioliasis in pregnant women at Al-Zahra Hospital, Rasht, northern Iran, in 2025.
Methods: For pregnant women visiting Al-Zahra Hospital in Rasht in 2025, data on demographics, clinical symptoms, and eosinophil levels were collected. 3 cc blood sample was taken from each participant, and an Indirect-ELISA test for IgG antibodies using Fasciola somatic antigen was conducted. Data were analyzed using SPSS version 25.
Results: The study included 365 pregnant women, aged 15–48 years (mean: 31.9±12.28) fascioliasis seroprevalence was 3.8% (95% CI: 2.1%–5.5%). Seropositive women were in 27–39 weeks of pregnancy. Most participants were urban (92.1%), 7.9% rural, and 98.6% consumed vegetables without proper disinfection. Seropositive women showed eosinophil percentages (2%–28%, mean: 4.9% ± 6.8%), with 28.5% having hyper-eosinophilia (>450/ml blood). Compared to seronegative women, they had higher WBC (11.2 ± 2.2 K/µL) and lower haemoglobin (11.6 ± 1.3 g/dL). Gastrointestinal symptoms were reported by 63.6% of participants, including 3.4% of seropositive cases.
Conclusion: Guilan Province is a key endemic area for fascioliasis in Iran. Pregnant women are at risk, as overlapping symptoms with pregnancy may delay diagnosis. Treatment during pregnancy carries risks of adverse effects. Thus, health education and proper vegetable-washing practices are advised for women of childbearing age in endemic regions.
Objective: This cross-sectional study evaluates the seroprevalence of fascioliasis in pregnant women at Al-Zahra Hospital, Rasht, northern Iran, in 2025.
Methods: For pregnant women visiting Al-Zahra Hospital in Rasht in 2025, data on demographics, clinical symptoms, and eosinophil levels were collected. 3 cc blood sample was taken from each participant, and an Indirect-ELISA test for IgG antibodies using Fasciola somatic antigen was conducted. Data were analyzed using SPSS version 25.
Results: The study included 365 pregnant women, aged 15–48 years (mean: 31.9±12.28) fascioliasis seroprevalence was 3.8% (95% CI: 2.1%–5.5%). Seropositive women were in 27–39 weeks of pregnancy. Most participants were urban (92.1%), 7.9% rural, and 98.6% consumed vegetables without proper disinfection. Seropositive women showed eosinophil percentages (2%–28%, mean: 4.9% ± 6.8%), with 28.5% having hyper-eosinophilia (>450/ml blood). Compared to seronegative women, they had higher WBC (11.2 ± 2.2 K/µL) and lower haemoglobin (11.6 ± 1.3 g/dL). Gastrointestinal symptoms were reported by 63.6% of participants, including 3.4% of seropositive cases.
Conclusion: Guilan Province is a key endemic area for fascioliasis in Iran. Pregnant women are at risk, as overlapping symptoms with pregnancy may delay diagnosis. Treatment during pregnancy carries risks of adverse effects. Thus, health education and proper vegetable-washing practices are advised for women of childbearing age in endemic regions.
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