Volume 6, Issue 23 And 24 (9-1997)
JGUMS 1997, 6(23 And 24): 35-42 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Mojtaba'ee H, Shafaghi . A, Ali-ee A. A Clinical Trial Study in Assessment of Effects of Vitamin E in Acute Hemolysis Attack in Glucose -6-phosphate Dehydrogenase DeficientPatients (Favism). JGUMS 1997; 6 (23 and 24) :35-42
URL: http://journal.gums.ac.ir/article-1-1853-en.html
URL: http://journal.gums.ac.ir/article-1-1853-en.html
Abstract: (9444 Views)
ABSTRACT
Glucose -6-phosphate dehydrogenase (G6PD)deficiency is the most common inheritory enzyme defect in human. With this deficiency, red blood cells are susceptible to hemolysis induced by oxidants .Drage and foods (esp. fava beans) are the most common oxidants that cause acute hemolysis (Favism).
Vitamin E.that is an potent antioxidant,was studied in chronic hemolysis of these patients. Our study indicates an hemoglobin increase after transfusion with Vitamin E consumption. We included 38 patients with acute hemolysis presentation that had a history of recent fava bean ingestion We divided the patients into two groups randomly.First group received vitamin E (800 U/day) and supportive care for hemolysis and the latter only supportive care as control group.
Means of hemoglobin differences were compared in two groups before transfusion and 4 hours after it and also mean hemoglobin differences between admission and discharge were greater in test grouprather than control group.
Vitamin E is a potent antitoxidant that can stablize RBC membrane and protect it against lysis. This drug have very few side effects and is a safe drug in usual dosage (400-1000 U/day).
Vitamin hemolysis can be used in treatment of acute hemolysis attacks of G6PD(Favism ).
Glucose -6-phosphate dehydrogenase (G6PD)deficiency is the most common inheritory enzyme defect in human. With this deficiency, red blood cells are susceptible to hemolysis induced by oxidants .Drage and foods (esp. fava beans) are the most common oxidants that cause acute hemolysis (Favism).
Vitamin E.that is an potent antioxidant,was studied in chronic hemolysis of these patients. Our study indicates an hemoglobin increase after transfusion with Vitamin E consumption. We included 38 patients with acute hemolysis presentation that had a history of recent fava bean ingestion We divided the patients into two groups randomly.First group received vitamin E (800 U/day) and supportive care for hemolysis and the latter only supportive care as control group.
Means of hemoglobin differences were compared in two groups before transfusion and 4 hours after it and also mean hemoglobin differences between admission and discharge were greater in test grouprather than control group.
Vitamin E is a potent antitoxidant that can stablize RBC membrane and protect it against lysis. This drug have very few side effects and is a safe drug in usual dosage (400-1000 U/day).
Vitamin hemolysis can be used in treatment of acute hemolysis attacks of G6PD(Favism ).
Keywords: Favism /Hemolysis /Vitamin E
Review Paper: Research |
Subject:
Special
Received: 2019/03/10 | Accepted: 2019/03/10 | Published: 2019/03/10
Received: 2019/03/10 | Accepted: 2019/03/10 | Published: 2019/03/10
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Copyright © The Author(s);
This is an open access article distributed under the terms of the
Creative Commons Attribution License (CC-By-NC),which permits use, distribution, and reproduction in any medium,
provided the original work is properly cited and is not used forcommercial purposes.
Contact Information
